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dc.contributor.authorBugge, Erlend
dc.contributor.authorNissen, Trygve
dc.contributor.authorWynn, Rolf
dc.date.accessioned2017-03-14T12:08:22Z
dc.date.available2017-03-14T12:08:22Z
dc.date.issued2016-12-08
dc.description.abstract<p><i>Background:</i> Clozapine is the archetypical atypical antipsychotic, its primary indication being treatment resistant schizophrenia. Severe side effects caused by clozapine, including leukopenia, agranulocytosis, and myocarditis, are well known. A rarely described side effect is concurrent perimyocarditis and parenchymal lung disease. <p><i>Case presentation:</i> A previously physically healthy 23-year-old male Caucasian that suffered from schizophrenia presented with flu-like symptoms 1 week after starting clozapine treatment. Treatment with clozapine was discontinued. He developed respiratory distress. Investigations showed significant parenchymal infiltration in both of the lungs, pericardial fluid, and heart failure. He initially received treatment for suspected malignant neuroleptic syndrome and later for suspected infection, but these tentative diagnoses were not confirmed. The patient’s condition gradually improved. In retrospect, clozapine-induced parenchymal lung disease and perimyocarditis were deemed the most probable causes. <p><i>Conclusions:</i> Concurrent perimyocarditis and parenchymal lung disease are rare side effects of clozapine. Clozapine-induced disease in general is considered an exclusion diagnosis. Lacking a verifiable diagnosis when suspecting a side effect of clozapine, clinicians might treat the most likely and serious condition presenting and consider discontinuing clozapine until the diagnostic uncertainty is reasonably resolved.en_US
dc.identifier.citationBugge E, Nissen T, Wynn R. Probable clozapine-induced parenchymal lung disease and perimyocarditis: A case report. BMC Psychiatry. 2016en_US
dc.identifier.cristinIDFRIDAID 1408327
dc.identifier.doi10.1186/s12888-016-1158-1
dc.identifier.issn1471-244X
dc.identifier.urihttps://hdl.handle.net/10037/10649
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.ispartofNissen, T. (2020). Medical case reports: Some theoretical and empirical perspectives. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19227>https://hdl.handle.net/10037/19227</a>
dc.relation.journalBMC Psychiatry
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry, child psychiatry: 757en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.subjectClozapineen_US
dc.subjectCase reporten_US
dc.subjectSide effectsen_US
dc.subjectPericarditisen_US
dc.subjectPerimyocarditisen_US
dc.subjectDiffuse parenchymal lung diseaseen_US
dc.subjectSchizophreniaen_US
dc.titleProbable clozapine-induced parenchymal lung disease and perimyocarditis: A case reporten_US
dc.type.versionpublishedVersion
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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