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The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort

Permanent lenke
https://hdl.handle.net/10037/11397
DOI
https://doi.org/10.18632/oncotarget.15817
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Åpne
article.pdf (2.065Mb)
(PDF)
Dato
2017-03-01
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Ness, Nora; Andersen, Sigve; Khanehkenari, Mehrdad Rakaee; Nordbakken, Cecilie V.; Valkov, Andre; Paulsen, Erna-Elise; Nordby, Yngve; Bremnes, Roy M.; Dønnem, Tom; Busund, Lill-Tove; Richardsen, Elin
Sammendrag
Programmed cell death protein 1 (PD-1) and its ligand Programmed death ligand 1 (PD-L1) have gained massive attention in cancer research due to recent availability and their targeted antitumor effects. Their role in prostate cancer is still undetermined. We constructed tissue microarrays from prostatectomy specimens from 535 prostate cancer patients. Following validation of antibodies, immunohistochemistry was used to evaluate the expression of PD-1 in lymphocytes and PD-L1 in epithelial and stromal cells of primary tumors. PD-L1 expression was commonly seen in tumor epithelial cells (92% of cases). Univariate survival analysis revealed a positive association between a high density of PD-1+ lymphocytes and worse clinical failure-free survival, limited to a trend (p = 0.084). In subgroups known to indicate unfavorable prostate cancer prognosis (Gleason grade 9, age < 65, preoperative PSA > 10, pT3) patients with high density of PD-1+ lymphocytes had a significantly higher risk of clinical failure (p = < 0.001, p = 0.025, p = 0.039 and p = 0.011, respectively). In the multivariate analysis, high density of PD-1+ lymphocytes was a significant negative independent prognostic factor for clinical failure-free survival (HR = 2.48, CI 95% 1.12–5.48, p = 0.025).
Er en del av
Ness, N. (2021). Immunological biomarkers in prostate cancer - A retrospective cohort study utilizing immunohistochemistry on tissue microarrays for evaluation of immune biomarker expression and experimental in vitro assays. (Doctoral thesis). https://hdl.handle.net/10037/21237.
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Impact Journals
Sitering
Ness N, Andersen S, Khanehkenari MR, et al. The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort. Oncotarget. 2017;8(16):26789-26801. doi:10.18632/oncotarget.15817.
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Samlinger
  • Artikler, rapporter og annet (medisinsk biologi) [1103]
  • Artikler, rapporter og annet (klinisk medisin) [1974]

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