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dc.contributor.authorRichardsen, Elin
dc.contributor.authorAndersen, Sigve
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorRakaee, Mehrdad
dc.contributor.authorNordby, Yngve
dc.contributor.authorPedersen, Mona Irene
dc.contributor.authorNess, Nora
dc.contributor.authorGrindstad, Thea K.W.
dc.contributor.authorMovik, Ingeborg
dc.contributor.authorDønnem, Tom
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.date.accessioned2018-01-25T08:32:44Z
dc.date.available2018-01-25T08:32:44Z
dc.date.issued2017-11-15
dc.description.abstractThe tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related outcomes of 535 patients treated with radical prostatectomy. The percentage of tumor epithelial cells expressing Ki-67 was determined by immunohistochemical assay, both digital image analysis and visual scoring by light microscope were used for quantification. The association of Ki-67 and prostate cancer was evaluated, as well as its prognostic value. There was a positive correlation between high expression of Ki-67 and Gleason score > 7 (p < 0.001) as well as tumor size ( 20 mm, p = 0.03). In univariate analyses, a high expression of Ki-67 in tumor epithelium was significantly associated with biochemical failure (BF) (digital scoring, p = 0.014) and (visual scoring, p = 0.004). In the multivariate analyses, a high level of Ki-67 was an independent poor prognostic factor for biochemical failure-free survival (BFFS) (Visual scoring, Ki67, p = 0.012, HR:1.50, CI95% 1.10±2.06). In conclusion, high Ki-67 expression is an independent negative prognostic marker for biochemical failure. Our findings support the role of Ki-67 as a significant, poor prognostic factor for in prostate cancer outcome.en_US
dc.descriptionSource at <a href=https://doi.org/10.1371/journal.pone.0186852> https://doi.org/10.1371/journal.pone.0186852 </a>en_US
dc.identifier.citationRichardsen E. et al. (2017) Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort. PLoS ONE 12(11): e0186852.en_US
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 1530594
dc.identifier.other10.1371/journal.pone.0186852
dc.identifier.urihttps://hdl.handle.net/10037/12053
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleEvaluation of the proliferation marker Ki-67 in a large prostatectomy cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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