Show simple item record

dc.contributor.authorNestvold, Janne M.
dc.contributor.authorWang, Mengyu
dc.contributor.authorCamilio, Ketil Andre
dc.contributor.authorZinöcker, Severin
dc.contributor.authorTjelle, Torunn Elisabeth
dc.contributor.authorLindberg, Alf
dc.contributor.authorHaug, Bengt Erik
dc.contributor.authorKvalheim, Gunnar
dc.contributor.authorSveinbjørnsson, Baldur
dc.contributor.authorRekdal, Øystein
dc.date.accessioned2018-03-15T12:18:09Z
dc.date.available2018-03-15T12:18:09Z
dc.date.issued2017-08-17
dc.description.abstractLTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant infiltration of CD8C T cells was observed in both treated and non-treated lesions, as shown by immunohistochemical and flow cytometric analysis. LTX-315 rapidly killed the cells in vitro with a lytic mode of action followed by the subsequent release of Danger-Associated Molecular Pattern (DAMP) molecules such as HMGB1, ATP and Cytochrome c. Together, our data demonstrate that LTX-315 represents a new approach to cancer immunotherapy, which has the potential as a novel immunotherapeutic agent.en_US
dc.descriptionSource at: <a href=https://doi.org/10.1080/2162402X.2017.1338236> https://doi.org/10.1080/2162402X.2017.1338236 </a>en_US
dc.identifier.citationNestvold, J. M., Wang, M., Camilio, K. A., Zinöcker, S., Tjelle, T. E., Lindberg, A., Haug, B. E., Kvalheim, G., Sveinbjørnsson, B. & Rekdal, Ø. (2017). Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model. Oncoimmunology, 6, 8:e1338236,1-13. https://doi.org/10.1080/2162402X.2017.1338236en_US
dc.identifier.cristinIDFRIDAID 1508953
dc.identifier.doi10.1080/2162402X.2017.1338236
dc.identifier.issn2162-402X
dc.identifier.urihttps://hdl.handle.net/10037/12344
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalOncoimmunology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.titleOncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma modelen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record