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dc.contributor.authorFiskum, Charlotte
dc.contributor.authorAndersen, Tonje Grønning
dc.contributor.authorBornas, Xavier
dc.contributor.authorAslaksen, Per M.
dc.contributor.authorFlaten, Magne A.
dc.contributor.authorJacobsen, Karl
dc.date.accessioned2018-07-06T08:28:56Z
dc.date.available2018-07-06T08:28:56Z
dc.date.issued2018-05-23
dc.description.abstractBackground: Internalizing psychopathology and dysregulated negative affect are characterized by dysregulation in the autonomic nervous system and reduced heart rate variability (HRV) due to increases in sympathetic activity alongside reduced vagal tone. The neurovisceral system is however, a complex nonlinear system, and nonlinear indices related to psychopathology are so far less studied in children. Essential nonlinear properties of a system can be found in two main domains: the informational domain and the invariant domain. sample entropy (SampEn) is a much-used method from the informational domain, while detrended fluctuation analysis (DFA) represents a widely-used method from the invariant domain. To see if nonlinear HRV can provide information beyond linear indices of autonomic activation, this study investigated SampEn and DFA as discriminators of internalizing psychopathology and negative affect alongside measures of vagally-mediated HRV and sympathetic activation.<p> Material and Methods: Thirty-Two children with internalizing difficulties and 25 healthy controls (aged 9–13) were assessed with the Child Behavior Checklist and the Early Adolescent Temperament Questionnaire, Revised, giving an estimate of internalizing psychopathology, negative affect and effortful control, a protective factor against psychopathology. Five minute electrocardiogram and impedance cardiography recordings were collected during a resting baseline, giving estimates of SampEn, DFA short-term scaling exponent α1, root mean square of successive differences (RMSSD), and pre-ejection period (PEP). Between-group differences and correlations were assessed with parametric and non-parametric tests, and the relationships between cardiac variables, psychopathology and negative affect were assessed using generalized linear modeling.<p> Results: SampEn and DFA were not significantly different between the groups. SampEn was weakly negatively related to heart rate (HR) in the controls, while DFA was moderately negatively related to RMSSD in both groups, and moderately positively related to HR in the clinical sample. SampEn was significantly associated with internalizing psychopathology and negative affect. DFA was significantly related to internalizing psychopathology.<p> Conclusions: Higher invariant self-similarity was linked to less psychopathology. Higher informational entropy was related to less psychopathology and less negative affect, and may provide an index of the organizational flexibility of the neurovisceral system.en_US
dc.description.sponsorshipNorwegian University for Science and Technologyen_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fphys.2018.00561> https://doi.org/10.3389/fphys.2018.00561 </a>.en_US
dc.identifier.citationFiskum, C., Andersen, T.G., Bornas, X., Aslaksen, P.M., Flaten, M.A. & Jacobsen, K. (2018). Non-linear heart rate variability as a discriminator of internalizing psychopathology and negative affect in children with internalizing problems and healthy controls. Frontiers in Physiology, 9, 1-15. https://doi.org/10.3389/fphys.2018.00561.en_US
dc.identifier.cristinIDFRIDAID 1592717
dc.identifier.doi10.3389/fphys.2018.00561
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/10037/13170
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Physiology
dc.rights.accessRightsopenAccessen_US
dc.subjectnon-linear time-series analysisen_US
dc.subjectHRVen_US
dc.subjectsample entropyen_US
dc.subjectRMSSDen_US
dc.subjectdetrended fluctuation analysisen_US
dc.subjectpreejection perioden_US
dc.subjectanxietyen_US
dc.subjectdepressionen_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.titleNon-linear heart rate variability as a discriminator of internalizing psychopathology and negative affect in children with internalizing problems and healthy controlsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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