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Serum osteoprotegerin and renal function in the general population: The Tromsø Study

Permanent link
https://hdl.handle.net/10037/13474
DOI
https://doi.org/10.1093/ckj/sfw095
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Date
2016-10-03
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne
Abstract

Background: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general population.

Methods: We conducted a cross-sectional study with 6689 participants recruited from the general population in Tromsø, Norway. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equations. OPG was modelled both as a continuous and categorical variable. General linear models and linear regression with adjustment for possible confounders were used to study the association between OPG and eGFR. Analyses were stratified by the median age, as serum OPG and age displayed a significant interaction on eGFR.

Results: In participants ≤62.2 years with normal renal function (eGFR ≥90 mL/min/1.73 m2) eGFR increased by 0.35 mL/min/1.73 m2 (95% CI 0.13–0.56) per 1 standard deviation (SD) increase in serum OPG after multiple adjustment. In participants older than the median age with impaired renal function (eGFR <90 mL/min/1.73 m2), eGFR decreased by 1.54 (95% CI −2.06 to −1.01) per 1 SD increase in serum OPG.

Conclusions: OPG was associated with an increased eGFR in younger subjects with normal renal function and with a decreased eGFR in older subjects with reduced renal function. Our findings imply that the association between OPG and eGFR varies with age and renal function.

Description
The following article: Vik, A., Brodin, E.E., Mathiesen, E.B., Brox, J., Jørgensen, L., Njølstad, I., ... Hansen, J.-B. (2017). Serum osteoprotegerin and renal function in the general population: The Tromsø Study. Clinical Kidney Journal, 10(1), 38-44. https://doi.org/10.1093/ckj/sfw095, has been accepted for publication in Clinical Kidney Journal Published by Oxford University Press. Source at https://doi.org/10.1093/ckj/sfw095. Published manuscript version, licensed CC BY-NC-ND 4.0.
Publisher
Oxford University Press (OUP)
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