Blar i tittel Artikler, rapporter og annet (farmasi)

Viser treff 338-357 av 358

    • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

      Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
      The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...

    • Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer 

      Kiselev, Yury; Andersen, Sigve; Johannessen, Charles; Fjukstad, Bjørn; Olsen, Karina Standahl; Stenvold, Helge; Al-Saad, Samer; Dønnem, Tom; Richardsen, Elin; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-22)
      Lung cancer is the leading cause of cancer deaths. Novel predictive biomarkers are needed to improve treatment selection and more accurate prognostication. PAX6 is a transcription factor with a proposed tumour suppressor function. Immunohistochemical staining was performed on tissue microarrays from 335 non-small cell lung cancer (NSCLC) patients for PAX6. Multivariate analyses of clinico-pathological ...

    • Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization 

      Warr, Alyson R; Hubbard, Troy P; Munera, Diana; Blondel, Carlos J; Abel zur Wiesch, Pia; Abel, Sören; Wang, Xiaoxue; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
      Enterohemorrhagic <i>Escherichia coli</i> O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and <i>E. coli</i> K-12 growth <i>in vitro</i> and for EHEC growth <i>in vivo</i> in the infant rabbit colon. Surprisingly, many conserved loci contribute to EHEC’s but not to K-12’s growth <i>in ...

    • A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults 

      Robinson, Eirin Guldsten; Gyllensten, Hanna; Johansen, Jeanette Schultz; Havnes, Kjerstin; Granås, Anne Gerd; Bergmo, Trine Strand; Småbrekke, Lars; Garcia, Beate Hennie; Halvorsen, Kjell Hermann (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
      Background - Older adults are at greater risk of medication-related harm than younger adults. The Integrated Medication Management model is an interdisciplinary method aiming to optimize medication therapy and improve patient outcomes.<p> <p>Objective - We aimed to investigate the cost effectiveness of a medication optimization intervention compared to standard care in acutely hospitalized older ...

    • Ulcerative colitis: Functional analysis of the in-depth proteome 

      Schniers, Armin; Goll, Rasmus; Pasing, Yvonne; Sørbye, Sveinung; Florholmen, Jon; Hansen, Terkel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      <p><i>Background - </i>Ulcerative colitis (UC) is one major form of inflammatory bowel disease. The cause and the pathophysiology of the disease are not fully understood and we therefor aim in this study to identify important pathophysiological features in UC from proteomics data. <p><i>Methods - </i>Colon mucosa biopsies from inflamed tissue of untreated UC patients at diagnosis and from healthy ...

    • Ultrasound-mediated destabilization and drug release from liposomes comprising dioleoylphosphatidylethanolamine 

      Evjen, Tove Julie; Nilssen, Esben A.; Barnert, Sabine; Schubert, Rolf; Brandl, Martin; Fossheim, Sigrid L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Novel sonosensitive doxorubicin-containing liposomes comprising dioleoylphosphatidylethanolamine (DOPE) as the main lipid constituent were developed and characterized in terms of ultrasound-mediated drug release in vitro. The liposome formulation showed high sonosensitivity; where approximately 95% doxorubicin was released from liposomes after 6 min of 40 kHz US exposure in buffered sucrose solution. ...

    • Understanding the binding of inhibitors of matrix metalloproteinases by molecular docking, quantum mechanical calculations, molecular dynamics simulations, and a MMGBSA/MMBappl study 

      Singh, Tanya; Adekoya, Olayiwola; Jayaram, B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-14)
      Matrix metalloproteinases (MMPs) consist of a class of proteins required for normal tissue function. Their over expression is associated with many disease states and hence the interest in MMPs as drug targets. Almost all MMP inhibitors have been reported to fail in clinical trials due to lack of specificity. Zinc in the binding site of metalloproteinases performs essential biological functions ...

    • Uptake and organ distribution of feed introduced plasmid DNA in growing or pregnant rats 

      Grønsberg, Idun; Nordgård, Lise; Fenton, Kristin Andreassen; Hegge, Beate; Nielsen, Kaare Magne; Bardocz, Susan; Pusztai, Arpad; Traavik, Ingemar Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

    • Use of 3-D modelling in early development phase of pectin tablets 

      Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This study examines the contribution of the 3-D model in an early development set-up for pectin tablets. Therefore, the aim of this work is to extract as much information on the compression behaviour from as few tablets as possible. Pectins with various degrees of methoxylation (DM) were studied (4-72%). The compressibility was evaluated by classical “in-die” Heckel and Kawakita analyses in addition ...

    • Use of a Commercially Available Microarray to Characterize Antibiotic-Resistant Clinical Isolates of Klebsiella pneumoniae 

      Charnock, Colin; Samuelsen, Ørjan; Nordlie, Anne-Lise; Hjeltnes, Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Commercially available microarray (IDENTIBAC AMR-ve) for the detection of antibiotic resistance determinants was investigated for its potential to genotype 30 clinical isolates and two control strains of Klebsiella pneumoniae. Resistance profiles and the production of extended-spectrum b-lactamases were determined by disc diffusion and the results were compared with the microarray profiles in order ...

    • Use of Selective Serotonin Reuptake Inhibitors – Validity of Self-Report versus Plasma Concentrations and Pharmacy Dispensations – A Cross-Sectional Analysis of the Norwegian Women and Cancer Study 

      Waaseth, Marit; Havelkova, Martina; Forsdahl, Guro; Lund, Eiliv; Log, Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-30)
      Purpose: To validate self-reported current use of selective serotonin reuptake inhibitors (SSRI) in the Norwegian Women and Cancer study (NOWAC) and to identify factors associated with discordance between data sources.<p> <p>Material and Methods: This is a cross-sectional record-linkage study comparing SSRI-use derived from four data sources: 1) Specific SSRI questions in the main NOWAC questionnaire, ...

    • Using chemical reaction kinetics to predict optimal antibiotic treatment strategies 

      Abel zur Wiesch, Pia; Clarelli, Fabrizio; Cohen, Ted (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-06)
      Identifying optimal dosing of antibiotics has proven challenging—some antibiotics are most effective when they are administered periodically at high doses, while others work best when minimizing concentration fluctuations. Mechanistic explanations for why antibiotics differ in their optimal dosing are lacking, limiting our ability to predict optimal therapy and leading to long and costly experiments. ...

    • Utvikling av utskrivningsintervensjon med fokus på riktig legemiddelbruk – en kvalitetsforbedringsstudie ved medisinsk avdeling 

      Garcia, Beate Hennie; Aag, Trine Iversen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      Hensikt - Hensikten med studien var å utvikle en utskrivningsintervensjon med fokus på riktig legemiddelbruk etter sykehusopphold. Involvering av farmasøyt var en forutsetning.<p> <p>Metode - Ved hjelp av forbedringsmetodikken plan-do-study-act (PDSA) har vi utviklet og evaluert en utskrivningsintervensjon hvor farmasøyten er sentral i samarbeid med det tverrfaglige teamet.<p> <p>Resultater - ...

    • The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations 

      Falavigna, Margherita; Pattacini, Martina; Wibel, Richard; Sonvico, Fabio; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-19)
      Drug administration to the vaginal site has gained increasing attention in past decades, highlighting the need for reliable in vitro methods to assess the performance of novel formulations. To optimize formulations destined for the vaginal site, it is important to evaluate the drug retention within the vagina as well as its permeation across the mucosa, particularly in the presence of vaginal fluids. ...

    • vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding 

      Tran, Vi Ngoc-Nha; Shams, Alireza; Ascioglu, Sinan; Martinecz, Antal; Liang, Jingyi; Clarelli, Fabrizio; Mostowy, Rafal; Cohen, Ted; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ...

    • Veitrafikkulykker knyttet til forskrivning av legemidler : En registerbasert kohortstudie 

      Skurtveit, Svetlana; Engeland, Anders; Bramness, Jørgen G.; Mørland, Jørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

    • Vurdering av publikasjonen: “Long term toxicity of a Roundup herbicide and a Rounduptolerant genetically modified maize” (Séralini et al. (2012), Food Chem Toxicol 50*). Uttalelse fra Faggruppen for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 

      Nerland, Audun Helge; Bakke, Anne Marie; Bernhoft, Aksel; Rivedal, Edgar; Torp, Torfinn; Brandtzæg, Per; Holck, Askild Lorentz; Junttila, Olavi; Konestabo, Heidi Sjursen; Meadow, Richard; Mikalsen, Arne; Nielsen, Kaare Magne; Sipinen, Ville Erling; Sorteberg, Hilde-Gunn Opsahl; Vikse, Rose; Andreassen, Åshild Kristine (Research report; Forskningsrapport, 2012-12-20)
      Den 19. september 2012 ble det publisert en artikkel i det tyske tidsskriftet «Food and Chemical Toxicology» som vakte oppmerksomhet i store deler av verden. Artikkelen bygger på en toårig fôringsstudie med rotter og konkluderer med en antatt økt hyppighet for ulike svulstdannelser og nyrelidelser blant dyrene knyttet til den genmodifiserte maisen NK603 og plantevernmidlet Roundup som inneholder ...

    • What do Australian consumers, pharmacists and prescribers think about documenting indications on prescriptions and dispensed medicines labels?: A qualitative study 

      Garada, Mona; McLachlan, Andrew J; Schiff, Gordon D; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
      Background: Documenting the indication on prescriptions and dispensed medicines labels is not standard practice in Australia. However, previous studies that have focused on the content and design of dispensed medicines labels, have suggested including the indication as a safety measure. The aim of this study was to investigate the perspectives of Australian consumers, pharmacists and prescribers ...

    • ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 

      Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
      Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, ...