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dc.contributor.authorSakshaug, Solveig
dc.contributor.authorHartz, Ingeborg
dc.contributor.authorFuru, Kari
dc.contributor.authorSkurtveit, Svetlana
dc.contributor.authorEngeland, Anders
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorNjølstad, Inger
dc.date.accessioned2008-04-01T12:54:22Z
dc.date.available2008-04-01T12:54:22Z
dc.date.issued2007-12-05
dc.description.abstractBackground: A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. Our objective was to explore how differences in prevalences of use, dosing characteristics, choice of statin and continuity of therapy in individual patients adds new information to previous results. Methods: Data were retrieved from The Norwegian Prescription Database. We included individuals from counties with high, average, and low statin consumption, who had at least one statin prescription dispensed during 2004 (N = 40 143). 1-year prevalence, prescribed daily dose (PDD), statin of choice, and continuity of therapy assessed by mean number of tablets per day. Results: The high-consumption county had higher prevalence of statin use in all age groups. Atorvastatin and simvastatin were dispensed in 79–87% of all statin users, and the proportion was significantly higher in the high-consumption county. The estimated PDDs were higher than the DDDs, up to twice the DDD for atorvastatin. The highconsumption county had the highest PDD for simvastatin (25.9 mg) and atorvastatin (21.9 mg), and more users received tablets in the upper range of available strengths. Continuity of therapy was similar in the three counties. Conclusion: Although differences in age-distribution seems to be an important source of variation in statin consumption, it cannot account for the total variation between counties in Norway. Variations in prevalences of use, and treatment intensity in terms of PDD and choice of statin also affect the total consumption. The results in this study seems to correspond to previous findings of more frequent statin use in primary prevention, and more statin users achieving lipid goal in the highest consuming county.en
dc.format.extent281745 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationBMC Clinical Pharmacology 7(2007) article no 14en
dc.identifier.doidoi:10.1186/1472-6904-7-14
dc.identifier.issn1472-6904
dc.identifier.urihttps://hdl.handle.net/10037/1388
dc.identifier.urnURN:NBN:no-uit_munin_1168
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.titleAspects of statin prescribing in Norwegian counties with high, average and low statin consumption : an individual-level prescription database studyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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