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dc.contributor.authorDorraji, Seyed Esmaeil
dc.contributor.authorHovd, Aud-Malin Karlsson
dc.contributor.authorKanapathippillai, Premasany
dc.contributor.authorBakland, Gunnstein
dc.contributor.authorEilertsen, Gro Østli
dc.contributor.authorFigenschau, Stine
dc.contributor.authorFenton, Kristin Andreassen
dc.date.accessioned2018-10-23T08:44:42Z
dc.date.available2018-10-23T08:44:42Z
dc.date.issued2018-05-18
dc.description.abstractTertiary lymphoid structures (TLS) develop in the kidneys of lupus-prone mice and systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Here we investigated the presence of mesenchymal stem cells (MSCs) in the development of TLS in murine LN, as well as the role of human MSCs as lymphoid tissue organizer (LTo) cells on the activation of CD4+ T cells from three groups of donors including Healthy, SLE and LN patients. Mesenchymal stem like cells were detected within the pelvic wall and TLS in kidneys of lupus-prone mice. An increase in LTβ, CXCL13, CCL19, VCAM1 and ICAM1 gene expressions were detected during the development of murine LN. Human MSCs stimulated with the pro-inflammatory cytokines TNF-α and IL-1β significantly increased the expression of CCL19, VCAM1, ICAM1, TNF-α, and IL-1β. Stimulated MSCs induced proliferation of CD4<sup>+</sup> T cells, but an inhibitory effect was observed when in co-culture with non-stimulated MSCs. A contact dependent increase in Th2 and Th17 subsets were observed for T cells from the Healthy group after co-culture with stimulated MSCs. Our data suggest that tissue-specific or/and migratory MSCs could have pivotal roles as LTo cells in accelerating early inflammatory processes and initiating the formation of kidney specific TLS in chronic inflammatory conditions.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authorityen_US
dc.descriptionCopyright Nature Research. Source at <a href=https://doi.org/10.1038/s41598-018-26265-z> https://doi.org/10.1038/s41598-018-26265-z</a>.en_US
dc.identifier.citationDorraji, S.D., Hovd, A.-M.K., Kanapathippillai, P., Bakland, G., Eilertsen, G.Ø., Figenschau, S.L. & Fenton, K.A. (2018). Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis. Scientific Reports, 8(7861). https://doi.org/10.1038/s41598-018-26265-zen_US
dc.identifier.cristinIDFRIDAID 1592711
dc.identifier.doi10.1038/s41598-018-26265-z
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/14013
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleMesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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