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dc.contributor.authorRekvig, Ole Petter
dc.date.accessioned2019-03-07T14:31:18Z
dc.date.available2019-03-07T14:31:18Z
dc.date.issued2018-03-01
dc.description.abstractSystemic lupus erythematosus (SLE) is an inadequately defined syndrome. Etiology and pathogenesis remain largely unknown. SLE is on the other hand a seminal syndrome that has challenged immunologists, biologists, genetics, and clinicians to solve its nature. The syndrome is characterized by multiple, etiologically unlinked manifestations. Unexpectedly, they seem to occur in different stochastically linked clusters, although single gene defects may promote a smaller spectrum of symptoms/criteria typical for SLE. There is no known inner coherence of parameters (criteria) making up the disease. These parameters are, nevertheless, implemented in The American College of Rheumatology (ACR) and The Systemic Lupus Collaborating Clinics (SLICC) criteria to classify SLE. Still, SLE is an abstraction since the ACR or SLICC criteria allow us to define hundreds of different clinical SLE phenotypes. This is a major point of the present discussion and uses “The anti-dsDNA antibody” as an example related to the problematic search for biomarkers for SLE. The following discussion will show how problematic this is: the disease is defined through non-coherent classification criteria, its complexity is recognized and accepted, its pathogenesis is plural and poorly understood. Therapy is focused on dominant symptoms or organ manifestations, and not on the syndrome itself. From basic scientific evidences, we can add substantial amount of data that are not sufficiently considered in clinical medicine, which may change the paradigms linked to what “The Anti-DNA antibody” is—and is not—in context of the imperfectly defined syndrome SLE.en_US
dc.description.sponsorshipUniversity of Tromsø Norwegian Center for Molecular Medicine, University of Osloen_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fimmu.2018.00387>https://doi.org/10.3389/fimmu.2018.00387. </a>en_US
dc.identifier.citationRekvig, O.P. (2018). Systemic lupus erythematosus: Definitions, contexts, conflicts, enigmas. <i>Frontiers in Immunology</i>, 9:387. https://doi.org/10.3389/fimmu.2018.00387en_US
dc.identifier.cristinIDFRIDAID 1629962
dc.identifier.doi10.3389/fimmu.2018.00387
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/14897
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.rights.accessRightsopenAccessen_US
dc.subjectsystemic lupus erythematosusen_US
dc.subjectsyndromeen_US
dc.subjectanti-dsDNA antibodiesen_US
dc.subjectcriteriaen_US
dc.subjectdefinitionsen_US
dc.subjectenigmaen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleSystemic lupus erythematosus: Definitions, contexts, conflicts, enigmasen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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