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dc.contributor.authorLiang, Robin Amanda
dc.contributor.authorHøiland, Ina Isabella
dc.contributor.authorUeland, Thor
dc.contributor.authorAukrust, Pål
dc.contributor.authorSnir, Omri
dc.contributor.authorHindberg, Kristian
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorGarred, Peter
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2019-09-13T08:59:05Z
dc.date.available2019-09-13T08:59:05Z
dc.date.issued2019-06-20
dc.description.abstract<i>Background</i> - Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease.<p> <p><i>Objectives</i> - To investigate the association between plasma MBL levels and future risk of incident VTE.<p> <p><i>Methods</i> - We conducted a nested case‐control study in 417 VTE patients and 849 age‐matched and sex‐matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme‐linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels.<p> <p><i>Results</i> - Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56‐1.10) and for DVT (OR 0.70, 95% CI: 0.47‐1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event.<p> <p><i>Conclusions</i> - Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.en_US
dc.description.sponsorshipStiftelsen Kristian Gerhard Jebsen The Danish Research Foundation for Independent Research Novo Foundation The Simon Fougner Hartmann Family Fund The Odd Fellow Foundation The Norwegian Council on Cardiovascular Diseaseen_US
dc.descriptionSource at <a href=https://doi.org/10.1111/jth.14539>https://doi.org/10.1111/jth.14539. </a>en_US
dc.identifier.citationLiang, R.A., Høiland, I.I., Ueland, T., Aukrust, P., Snir, O., Hindberg, K. ... Hansen, J.B. (2019). Plasma levels of mannose-binding lectin and future risk of venous thromboembolism. <i>Journal of Thrombosis and Haemostasis</i>. https://doi.org/10.1111/jth.14539en_US
dc.identifier.cristinIDFRIDAID 1722878
dc.identifier.doi10.1111/jth.14539
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/16191
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofLiang, R.A. (2019). Role of Mannose-Binding Lectin and Complement Activation in Venous Thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/17027>https://hdl.handle.net/10037/17027</a>.
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.subjectcomplementen_US
dc.subjectdeep vein thrombosisen_US
dc.subjectmannose‐binding lectinen_US
dc.subjectpulmonary embolismen_US
dc.subjectvenous thromboembolismen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.titlePlasma levels of mannose-binding lectin and future risk of venous thromboembolismen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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