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dc.contributor.authorJebsen, Nina Louise
dc.contributor.authorApelseth, Torunn Oveland
dc.contributor.authorHaugland, Hans Kristian
dc.contributor.authorRekdal, Øystein
dc.contributor.authorPatel, Hamina
dc.contributor.authorGjertsen, Bjørn Tore
dc.contributor.authorJøssang, Dag Eirik
dc.date.accessioned2019-10-17T09:29:51Z
dc.date.available2019-10-17T09:29:51Z
dc.date.issued2019-06-10
dc.description.abstract<p><i>Background - </i>Desmoid tumors are intermediary malignant, fibrous lesions occurring in various soft tissues. Surgical treatment is relentlessly challenging because of the propensity for local aggressive behavior and high risk of recurrence. Consequently, a wide range of oncological drugs and radiation therapy are being used; however, outcomes are unpredictable. We investigated whether local treatment with an oncolytic peptide could be beneficial in a patient with an unresectable desmoid tumor. <p><i>Case presentation - </i>In a young 29-year-old Caucasian woman who was diagnosed with a retromammary desmoid tumor infiltrating deeply into the anterior thoracic wall, surgery was considered excessively mutilating, and observation was recommended. The lesion progressed, however, and caused debilitating pain, despite nonsteroidal anti-inflammatory medication. Subcutaneous injections of human interferon-α (Multiferon®) resulted in reduced growth kinetics but had to be terminated because of development of symptomatic pneumonitis. Frequently used oncological treatment was withheld because of the toxicity profile, and the patient was instead included in a phase I study investigating transdermal intratumoral injection of LTX-315, an oncolytic peptide that induces anticancer immune responses (ClinicalTrials.gov, NCT01986426). A marked increase of CD8+ tumor-infiltrating T cells in the lesion was complemented by upregulation of immune gene signature (including effector T-cell, T-helper type 1 cell, chemokine, and cytokine genes). These changes were followed by gradual symptom relief and long-term disease stabilization, indicating clinical benefit. LTX-315 was well tolerated until termination in week 16 after a serious allergic reaction. <p><i>Conclusions - </i>Our patient was treated with repeated intratumoral injections of LTX-315, resulting in tumor regression accompanied by upregulation of immune genes and T-cell infiltration. Local application of immunotherapy, minimizing systemic side effects, represents a novel treatment modality in desmoid tumors that should be tested in further clinical trials.en_US
dc.descriptionSource at <a href=https://doi.org/10.1186/s13256-019-2088-6>https://doi.org/10.1186/s13256-019-2088-6</a>.en_US
dc.identifier.citationJebsen, N.L., Apelseth, T.O., Haugland, H.K., Rekdal, Ø., Patel, H., Gjertsen, B.T. & Jøssang, D.E. (2019). Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: A case report. <i>Journal of Medical Case Reports, 13</i>, 177. https://doi.org/10.1186/s13256-019-2088-6en_US
dc.identifier.cristinIDFRIDAID 1712946
dc.identifier.doi10.1186/s13256-019-2088-6
dc.identifier.issn1752-1947
dc.identifier.urihttps://hdl.handle.net/10037/16430
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalJournal of Medical Case Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectDesmoid tumorsen_US
dc.subjectIntratumoral oncolytic peptideen_US
dc.subjectT-cell infiltrationen_US
dc.subjectImmune gene expression profilesen_US
dc.titleEnhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case reporten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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