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dc.contributor.authorTorvik, Fartein Ask
dc.contributor.authorRosenström, Tom Henrik
dc.contributor.authorGustavson, Kristin
dc.contributor.authorYstrøm, Eivind
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorCzajkowski, Nikolai Olavi
dc.contributor.authorReichborn-Kjennerud, Ted
dc.date.accessioned2020-01-15T09:35:48Z
dc.date.available2020-01-15T09:35:48Z
dc.date.issued2019-03-05
dc.description.abstract<p><i>Background - </i>It is unknown whether social anxiety disorder (SAD) has a unique association with alcohol use disorder (AUD) over and beyond that of other anxiety disorders, how the associations develop over time, and whether the associations are likely to be causal. <p><i>Methods - </i>Diagnoses of AUD, SAD, generalized anxiety disorder, panic disorder, agoraphobia, and specific phobias were assessed twice using the Composite International Diagnostic Interview among 2,801 adult Norwegian twins. The data were analyzed using logistic regression analyses and multivariate biometric structural equation modeling. <p><i>Results - </i>SAD had the strongest association with AUD, and SAD predicted AUD over and above the effect of other anxiety disorders. In addition, SAD was prospectively associated with AUD, whereas other anxiety disorders were not. AUD was associated with a slightly elevated risk of later anxiety disorders other than SAD. Biometric modeling favored a model where SAD influenced AUD compared to models where the relationship was reversed or due to correlated risk factors. Positive associations between AUD and other anxiety disorders were fully explained by shared genetic risk factors. <p><i>Conclusions - </i>Unlike other anxiety disorders, SAD plausibly has a direct effect on AUD. Interventions aimed at prevention or treatment of SAD may have an additional beneficial effect of preventing AUD, whereas interventions aimed at other anxiety disorders are unlikely to have a similar sequential effect on AUD.en_US
dc.descriptionThis is the peer reviewed version of the following article: Torvik, F.A., Rosenström, T.H., Gustavson, K.B., Ystrøm, E., Kendler, K.S., Bramness, J.G., Czajkowski, N.O. & Reichborn-Kjennerud, T. (2019). Explaining the association between anxiety disorders and alcohol use disorder: A twin study. <i>Depression and Anxiety, 36</i>(6), 522-532, which has been published in final form at <a href=https://doi.org/10.1002/da.22886>https://doi.org/10.1002/da.22886</a>. This article may be used for non-commercial purposes in accordance with <a href=https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html>Wiley Terms and Conditions for Use of Self-Archived Versions</a>.en_US
dc.identifier.citationTorvik, F.A., Rosenström, T.H., Gustavson, K.B., Ystrøm, E., Kendler, K.S., Bramness, J.G., Czajkowski, N.O. & Reichborn-Kjennerud, T. (2019). Explaining the association between anxiety disorders and alcohol use disorder: A twin study. <i>Depression and Anxiety, 36</i>(6), 522-532. https://doi.org/10.1002/da.22886en_US
dc.identifier.cristinIDFRIDAID 1697661
dc.identifier.doi10.1002/da.22886
dc.identifier.issn1091-4269
dc.identifier.issn1520-6394
dc.identifier.urihttps://hdl.handle.net/10037/17097
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalDepression and Anxiety
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEDREHELSE/240061/Norway/Long term outcomes of alcohol use and use disorders: a prospective twin study//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/262700/Norway/Centre for Fertility and Health , Senter for fruktbarhet og helse//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMED2/262177/Norway/Intergenerational Transmission of Internalizing and Externalizing Psychopathological Spectra: A Genome-Wide Complex Trait Study//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 Wiley Periodicals, Inc.en_US
dc.subjectVDP::Social science: 200::Psychology: 260::Personality psychology: 264en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Personlighetspsykologi: 264en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Psychiatry, child psychiatry: 757en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en_US
dc.titleExplaining the association between anxiety disorders and alcohol use disorder: A twin studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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