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dc.contributor.authorSletten, Elise Thoresen
dc.contributor.authorArnes, Marit
dc.contributor.authorLyså, Lena Marianne Myreng
dc.contributor.authorLarsen, Marthe
dc.contributor.authorØrbo, Anne
dc.date.accessioned2020-01-15T15:39:55Z
dc.date.available2020-01-15T15:39:55Z
dc.date.issued2019-01-25
dc.description.abstract<p><i>Objective - </i>After successful progestin therapy for endometrial hyperplasia (EH), the risk of relapse remains. We aimed to assess if immunohistochemical (IHC) expression of progesterone receptor isoforms, PR‐A and PR‐B, in endometrial glands and stroma in pre‐treatment endometrial biopsies was related to relapse of EH. <p><i>Design and setting - </i>Biopsy material originated from women with low‐risk and medium‐risk EH recruited to a recent Norwegian multicentre randomised trial. Participants (n = 153) had been treated for 6 months with three different progestin regimens. <p><i>Population - </i>One hundred and thirty‐five of the 153 women achieved therapy response and underwent follow up for 24 months after therapy withdrawal. Fifty‐five women relapsed during follow up. Pre‐treatment endometrial biopsies from 94 of the 135 responding women were available for IHC staining. <p><i>Methods - </i>Immunohistochemical staining was performed separately for PR‐A and PR‐B and IHC expression was evaluated in endometrial glands and stroma by a histological score (H‐score) using light microscopy. <p><i>Main outcome measure - </i>Immunohistochemical expression of PR‐A and PR‐B in endometrial glands and stroma in women with or without relapse of EH. <p><i>Results - </i>Low PR‐A in endometrial glands (P = 0.013) and stroma (P < 0.001), and high PR‐B in endometrial glands (P = 0.001) in pre‐treatment endometrial biopsy have a statistically significant association with relapse of EH. Women with a pre‐treatment ratio of PR‐A:PR‐B ≤ 1 have a higher risk of relapse (71%) compared with women with a ratio of PR‐A:PR‐B > 1 (19%; P < 0.001). <p><i>Conclusion - </i>Immunohistochemical expression of PR‐A and PR‐B in pre‐treatment endometrial biopsy proves valuable as a predictor of relapse in EH.en_US
dc.descriptionThis is the peer reviewed version of the following article: Sletten, E.T., Arnes, M., Lyså, L.M., Larsen, M. & Ørbo, A. (2019). Significance of progesterone receptors (PR-A and PR-B) expression as predictors for relapse after successful therapy of endometrial hyperplasia: a retrospective cohort study. <i>BJOG: an International Journal of Obstetrics and Gynaecology, 126</i>(7), 936-943, which has been published in final form at <a href=https://doi.org/10.1111/1471-0528.15579>https://doi.org/10.1111/1471-0528.15579</a>. This article may be used for non-commercial purposes in accordance with <a href=https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html>Wiley Terms and Conditions for Use of Self-Archived Versions</a>.en_US
dc.identifier.citationSletten, E.T., Arnes, M., Lyså, L.M., Larsen, M. & Ørbo, A. (2019). Significance of progesterone receptors (PR-A and PR-B) expression as predictors for relapse after successful therapy of endometrial hyperplasia: a retrospective cohort study. <i>BJOG: an International Journal of Obstetrics and Gynaecology, 126</i>(7), 936-943. https://doi.org/10.1111/1471-0528.15579en_US
dc.identifier.cristinIDFRIDAID 1690676
dc.identifier.doi10.1111/1471-0528.15579
dc.identifier.issn1470-0328
dc.identifier.issn1471-0528
dc.identifier.urihttps://hdl.handle.net/10037/17109
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalBJOG: an International Journal of Obstetrics and Gynaecology
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2018 Royal College of Obstetricians and Gynaecologistsen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US
dc.titleSignificance of progesterone receptors (PR-A and PR-B) expression as predictors for relapse after successful therapy of endometrial hyperplasia: a retrospective cohort studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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