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dc.contributor.authorJohansen, Terje
dc.contributor.authorLamark, Trond
dc.date.accessioned2020-03-17T08:30:29Z
dc.date.available2020-03-17T08:30:29Z
dc.date.issued2019-07-13
dc.description.abstractSelective autophagy relies on soluble or membrane-bound cargo receptors that recognize cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors interact with lipidated ATG8 family proteins anchored in the membrane at the concave side of the forming autophagosome. The interaction is mediated by 15- to 20-amino-acid-long sequence motifs called LC3-interacting region (LIR) motifs that bind to the LIR docking site (LDS) of ATG8 proteins. In this review, we focus on LIR–ATG8 interactions and the soluble mammalian selective autophagy receptors. We discuss the roles of ATG8 family proteins as membrane scaffolds in autophagy and the LIR–LDS interaction and how specificity for binding to GABARAP or LC3 subfamily proteins is achieved. We also discuss atypical LIR–LDS interactions and a novel LIR-independent interaction. Recently, it has become clear that several of the soluble cargo receptors are able to recruit components of the core autophagy apparatus to aid in assembling autophagosome formation at the site of cargo sequestration. A model on phagophore recruitment and expansion on a selective autophagy receptor-coated cargo incorporating the latest findings is presented.en_US
dc.identifier.citationJohansen T, Lamark T. Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors. Journal of Molecular Biology. 2019:1-24en_US
dc.identifier.cristinIDFRIDAID 1718601
dc.identifier.doi10.1016/j.jmb.2019.07.016
dc.identifier.issn0022-2836
dc.identifier.issn1089-8638
dc.identifier.urihttps://hdl.handle.net/10037/17761
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Molecular Biology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/249884/Norway/Autophagy-regulated Signalosomes in Cellular Stress and Disease Pathways//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleSelective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptorsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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