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dc.contributor.authorKehl, Stephanie R
dc.contributor.authorSoos, Brandy-Lee A
dc.contributor.authorSaha, Bhaskar
dc.contributor.authorChoi, Seong Won
dc.contributor.authorHerren, Anthony W
dc.contributor.authorJohansen, Terje
dc.contributor.authorMandell, Michael A
dc.date.accessioned2020-03-18T07:09:46Z
dc.date.available2020-03-18T07:09:46Z
dc.date.issued2019-07-25
dc.description.abstractThe protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro‐inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here, we show that TAK1, a kinase involved in immune signaling, negatively regulates p62 action in autophagy. TAK1 reduces p62 localization to autophagosomes, dampening the autophagic degradation of both p62 and p62‐directed autophagy substrates. TAK1 also relocalizes p62 into dynamic cytoplasmic bodies, a phenomenon that accompanies the stabilization of TAK1 complex components. On the other hand, p62 facilitates the assembly and activation of TAK1 complexes, suggesting a connection between p62's signaling functions and p62 body formation. Thus, TAK1 governs p62 action, switching it from an autophagy receptor to a signaling platform. This ability of TAK1 to disable p62 as an autophagy receptor may allow certain autophagic substrates to accumulate when needed for cellular functions.en_US
dc.identifier.citationKehl, Soos, Saha, Choi SW, Herren AW, Johansen T, Mandell MA. TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform. EMBO Reports. 2019;20(9)en_US
dc.identifier.cristinIDFRIDAID 1742222
dc.identifier.doi10.15252/embr.201846238
dc.identifier.issn1469-221X
dc.identifier.issn1469-3178
dc.identifier.urihttps://hdl.handle.net/10037/17778
dc.language.isoengen_US
dc.publisherEMBO Pressen_US
dc.relation.journalEMBO Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleTAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platformen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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