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dc.contributor.authorRasmussen, Trude Victoria
dc.contributor.authorAhlen, Maria Therese
dc.date.accessioned2020-03-30T11:07:10Z
dc.date.available2020-03-30T11:07:10Z
dc.date.issued2019-12-31
dc.description.abstractMaternal alloimmunization to paternally inherited antigens on fetal/neonatal platelets can cause fetal/neonatal alloimmune thrombocytopenia (FNAIT) after antibody-mediated removal of platelets from the fetal circulation. The complications vary from mild bleeding symptoms to severe intracranial hemorrhage and subsequent neurological impairment or death. Studies on <i>in vivo</i> mechanisms are challenging to measure directly in pregnant women, rendering murine models as valuable and attractive alternatives, despite some critical differences between mice and men affecting the translational value. Here we present and discuss, the different murine models that substantially have increased our knowledge and understanding of FNAIT pathogenesis – as well as pre-clinical evaluation of therapeutic and preventive strategies.en_US
dc.identifier.citationRasmussen TV, Ahlen MT. Murine models for studying treatment, prevention and pathogenesis of FNAIT. Transfusion and Apheresis Science. 2019en_US
dc.identifier.cristinIDFRIDAID 1777941
dc.identifier.doihttps://doi.org/10.1016/j.transci.2019.102706
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.urihttps://hdl.handle.net/10037/17911
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofMørtberg, T.V. (2023). Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) by prophylactic monoclonal antibodies. In vitro and preclinical evaluation of HPA-1a-specific antibodies. (Doctoral thesis). <a href=https://hdl.handle.net/10037/31366>https://hdl.handle.net/10037/31366</a>.
dc.relation.journalTransfusion and Apheresis Science
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleMurine models for studying treatment, prevention and pathogenesis of FNAITen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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