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dc.contributor.authorFang, Qing
dc.contributor.authorMaglangit, Fleurdeliz
dc.contributor.authorWu, Linrui
dc.contributor.authorEbel, Rainer
dc.contributor.authorKyeremeh, Kwaku
dc.contributor.authorAndersen, Jeanette Hammer
dc.contributor.authorAnnang, Frederick
dc.contributor.authorPérez-Moreno, Guiomar
dc.contributor.authorReyes, Fernando
dc.contributor.authorDeng, Hai
dc.date.accessioned2020-11-11T13:01:21Z
dc.date.available2020-11-11T13:01:21Z
dc.date.issued2020-01-22
dc.description.abstract<i>Streptomyces</i> remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of <i>Streptomyces</i> sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the characterization of a new 2-alkyl-4-hydroxymethylfuran carboxamide (AHFA) together with five known compounds, cyclo-(L-Pro-Gly), cyclo-(L-Pro-L-Phe), cyclo-(L-Pro-L-Val), cyclo-(L-Leu-Hyp), and deferoxamine E. AHFA, a methylenomycin (MMF) homolog, exhibited anti-proliferative activity (EC<sub>50</sub> = 89.6 µM) against melanoma A2058 cell lines. This activity, albeit weak is the first report amongst MMFs. Furthermore, the putative biosynthetic gene cluster (<i>ahfa</i>) was identified for the biosynthesis of AHFA 1. DFO-E 6 displayed potent anti-plasmodial activity (IC<sub>50</sub> = 1.08 µM) against <i>P. falciparum</i> 3D7. High-resolution electrospray ionization mass spectrometry (HR ESIMS) and molecular network assisted the targeted-isolation process, and tentatively identified six AHFA analogues, and six siderophores.en_US
dc.identifier.citationFang, Maglangit, Wu, Ebel, Kyeremeh, Andersen, Annang, Pérez-Moreno, Reyes, Deng. Signalling and bioactive metabolites from Streptomyces sp. RK44. Molecules. 2020;25(3):1-13en_US
dc.identifier.cristinIDFRIDAID 1836323
dc.identifier.doi10.3390/molecules25030460
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/19818
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMolecules
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470en_US
dc.titleSignalling and bioactive metabolites from Streptomyces sp. RK44en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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