ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for psykologi
  • Artikler, rapporter og annet (psykologi)
  • Vis innførsel
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for psykologi
  • Artikler, rapporter og annet (psykologi)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

Age-dependent effects of protein restriction on dopamine release

Permanent lenke
https://hdl.handle.net/10037/20111
DOI
https://doi.org/10.1038/s41386-020-0783-z
Thumbnail
Åpne
article.pdf (2.531Mb)
Publisert versjon (PDF)
Dato
2021-07-31
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Naneix, Fabien; Peters, Kate Z.; Young, Andrew J.; McCutcheon, James Edgar
Sammendrag
Despite the essential role of protein intake for health and development, very little is known about the impact of protein restriction on neurobiological functions, especially at different stages of the lifespan. The dopamine system is a central actor in the integration of food-related processes and is influenced by physiological state and food-related signals. Moreover, it is highly sensitive to dietary effects during early life periods such as adolescence due to its late maturation. In the present study, we investigated the impact of protein restriction either during adolescence or adulthood on the function of the mesolimbic (nucleus accumbens) and nigrostriatal (dorsal striatum) dopamine pathways using fast-scan cyclic voltammetry in rat brain slices. In the nucleus accumbens, protein restriction in adults increased dopamine release in response to low and high frequency trains of stimulation (1–20 Hz). By contrast, protein restriction during adolescence decreased nucleus accumbens dopamine release. In the dorsal striatum, protein restriction at adulthood has no impact on dopamine release but the same diet during adolescence induced a frequency-dependent increase in stimulated dopamine release. Taken together, our results highlight the sensitivity of the different dopamine pathways to the effect of protein restriction, as well as their vulnerability to deleterious diet effects at different life stages.
Forlag
Springer
Sitering
Naneix F, Peters KZ, Young AJ, McCutcheon JE. Age-dependent effects of protein restriction on dopamine release. Neuropsychopharmacology. 2021;46(2):394-403
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (psykologi) [561]
Copyright 2021 The Author(s)

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring