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dc.contributor.authorThorsen, Lene
dc.contributor.authorHaugnes, Hege Sagstuen
dc.contributor.authorFosså, Sophie Dorothea
dc.contributor.authorBrydøy, Marianne
dc.contributor.authorTandstad, Torgrim
dc.contributor.authorWisløff, Torbjørn
dc.contributor.authorGjerset, Gunhild Maria
dc.contributor.authorEdvardsen, Elisabeth
dc.contributor.authorLarsen, Karl-Otto
dc.contributor.authorSandset, Per Morten
dc.contributor.authorHenriksson, Carola
dc.contributor.authorRaastad, Truls
dc.contributor.authorNegaard, Helene Francisca Stigter
dc.date.accessioned2021-01-08T10:07:04Z
dc.date.available2021-01-08T10:07:04Z
dc.date.issued2020-06-11
dc.description.abstractThe randomized “Testicular cancer and Aerobic and Strength Training trial” (TAST‐trial) aimed to evaluate the effect of high‐intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin‐based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 to 60 years with a diagnosis of metastatic germ cell TC, planned for 3 to 4 CBCT cycles, were randomized to a 9 to 12 weeks exercise intervention, or to a single lifestyle counseling session. The exercise intervention included two weekly HIIT sessions, each with 2 to 4 intervals of 2 to 4 minutes at 85% to 95% of peak heart rate. The study was prematurely discontinued after inclusion of 19 of the planned 94 patients, with nine patients randomized to the intervention arm and 10 to the control arm. Three patients in the intervention arm developed TE complications; two with pulmonary embolism and one with myocardial infarction. All three patients had clinical stage IIA TC. No TE complications were observed among patients in the control arm. Our observations indicate that high‐intensity aerobic training during CBCT might increase the risk of TE events in TC patients, leading to premature closure of the TAST‐trial.en_US
dc.identifier.citationThorsen L, Haugnes h, Fosså SD, Brydøy M, Tandstad T, Wisløff T, Gjerset GM, Edvardsen E, Larsen K, Sandset PM, Henriksson C, Raastad T, Negaard HFS. Thromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literature. International Journal of Cancer. 2020;147(11):3189-3198en_US
dc.identifier.cristinIDFRIDAID 1847268
dc.identifier.doi10.1002/ijc.33151
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/20223
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/218312/Norway/Late effects - early detection, follow-up and treatment//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleThromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literatureen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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