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dc.contributor.authorKjær, Mette
dc.contributor.authorGeisen, Christof
dc.contributor.authorAkkøk, Cigdem Ahaein
dc.contributor.authorWikman, Agneta
dc.contributor.authorSachs, Ulrich
dc.contributor.authorBussel, James B.
dc.contributor.authorNielsen, Kaspar
dc.contributor.authorWalles, Katarina
dc.contributor.authorCurtis, Brian R.
dc.contributor.authorVidarsson, Gestur
dc.contributor.authorJärås, Kerstin
dc.contributor.authorSkogen, Bjørn
dc.date.accessioned2021-01-11T12:29:18Z
dc.date.available2021-01-11T12:29:18Z
dc.date.issued2019-12-31
dc.description.abstractAnti-HPA-1a-antibodies are the main cause of fetal and neonatal alloimmune thrombocytopenia (FNAIT) which may result in intracranial hemorrhage (ICH) and death among fetuses and newborns. Advances in understanding the pathogenesis of FNAIT and proof of concept for prophylaxis to prevent immunization suggest that development of hyperimmune anti-HPA-1a IgG aimed at preventing immunization against HPA-1a and FNAIT is feasible. Anti-HPA-1a IgG can be obtained either by isolating immunoglobulin from already-immunized women or by development of monoclonal anti-HPA-1a antibodies.<p> <p>Here we discuss recent advances that may lead to the development of a prenatal and postnatal prophylactic treatment for the prevention of HPA-1a-associated FNAIT and life-threatening FNAIT-induced complications.en_US
dc.identifier.citationKjær MK, Geisen, Akkøk CA, Wikman A, Sachs, Bussel JB, Nielsen, Walles, Curtis BR, Vidarsson G, Järås K, Skogen br. Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia. Transfusion and Apheresis Science. 2020;59:102712(1):1-6en_US
dc.identifier.cristinIDFRIDAID 1806595
dc.identifier.doi10.1016/j.transci.2019.102712
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.urihttps://hdl.handle.net/10037/20264
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalTransfusion and Apheresis Science
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/PROFNAIT/305986/Norway/Development of a prophylactic treatment for the prevention of fetal/neonatal alloimmune thrombocytopenia/FNAIT/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleStrategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopeniaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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