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dc.contributor.authorJacomin, Anne-Claire
dc.contributor.authorPetridi, Stavroula
dc.contributor.authorDi Monaco, Marisa
dc.contributor.authorBhujabal, Zambarlal
dc.contributor.authorJain, Ashish
dc.contributor.authorMulakkal, Nitha C.
dc.contributor.authorPalara, Anthimi
dc.contributor.authorPowell, Emma L.
dc.contributor.authorChung, Bonita
dc.contributor.authorZampronio, Cleidiane
dc.contributor.authorJones, Alexandra
dc.contributor.authorCameron, Alexander
dc.contributor.authorJohansen, Terje
dc.contributor.authorNezis, Ioannis P.
dc.date.accessioned2021-01-19T14:34:08Z
dc.date.available2021-01-19T14:34:08Z
dc.date.issued2020-05-26
dc.description.abstractAutophagy is the degradation of cytoplasmic material through the lysosomal pathway. One of the most studied autophagy-related proteins is LC3. Despite growing evidence that LC3 is enriched in the nucleus, its nuclear role is poorly understood. Here, we show that <i>Drosophila</i> Atg8a protein, homologous to mammalian LC3, interacts with the transcription factor Sequoia in a LIR motif-dependent manner. We show that Sequoia depletion induces autophagy in nutrient-rich conditions through the enhanced expression of autophagy genes. We show that Atg8a interacts with YL-1, a component of a nuclear acetyltransferase complex, and that it is acetylated in nutrient-rich conditions. We also show that Atg8a interacts with the deacetylase Sir2, which deacetylates Atg8a during starvation to activate autophagy. Our results suggest a mechanism of regulation of the expression of autophagy genes by Atg8a, which is linked to its acetylation status and its interaction with Sequoia, YL-1, and Sir2.en_US
dc.identifier.citationJacomin, Petridi, Di Monaco, Bhujabal, Jain, Mulakkal, Palara, Powell, Chung, Zampronio, Jones, Cameron, Johansen, Nezis. Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila. Cell reports. 2020;31(8):e1-e4en_US
dc.identifier.cristinIDFRIDAID 1848411
dc.identifier.doi10.1016/j.celrep.2020.107695
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/10037/20321
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalCell reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/249884/Norway/Autophagy-regulated Signalosomes in Cellular Stress and Disease Pathways//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleRegulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophilaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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