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dc.contributor.authorIakunchykova, Olena
dc.contributor.authorAverina, Maria
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWatkins, Hugh
dc.contributor.authorMalyutina, Sofia
dc.contributor.authorRagino, Yulia
dc.contributor.authorKeogh, Ruth
dc.contributor.authorKudryavtsev, Alexander V
dc.contributor.authorGovorun, Vadim
dc.contributor.authorCook, Sarah Anne
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorLeon, David Adrew
dc.date.accessioned2021-02-27T21:29:22Z
dc.date.available2021-02-27T21:29:22Z
dc.date.issued2020-05-15
dc.description.abstract<p><i>Background - </i>Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers between these two populations can help identify reasons for this substantial difference in risk. <p><i>Methods - </i>We compared age-standardised mean levels of CVD biomarkers for men and women aged 40–69 years measured in two cross-sectional population-based studies: Know Your Heart (KYH) (Russia, 2015–2018; n=4046) and the seventh wave of the Tromsø Study (Tromsø 7) (Norway, 2015–2018; n=17 646). A laboratory calibration study was performed to account for inter-laboratory differences. <p><i>Results - </i>Levels of total, low-density lipoprotein-, high-density lipoprotein-cholesterol and triglycerides were comparable in KYH and Tromsø 7 studies. N-terminal pro-b-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity C-reactive protein (hsCRP) were higher in KYH compared with Tromsø 7 (NT-proBNP was higher by 54.1% (95% CI 41.5% to 67.8%) in men and by 30.8% (95% CI 22.9% to 39.2%) in women; hs-cTnT—by 42.4% (95% CI 36.1% to 49.0%) in men and by 68.1% (95% CI 62.4% to 73.9%) in women; hsCRP—by 33.3% (95% CI 26.1% to 40.8%) in men and by 35.6% (95% CI 29.0% to 42.6%) in women). Exclusion of participants with pre-existing coronary heart disease (279 men and 282 women) had no substantive effect. <p><i>Conclusions - </i>Differences in cholesterol fractions cannot explain the difference in CVD mortality rate between Russia and Norway. A non-ischemic pathway to the cardiac damage reflected by raised NT-proBNP and hs-cTnT is likely to contribute to high CVD mortality in Russia.en_US
dc.identifier.citationIakunchykova O, Averina M, Wilsgaard T, Watkins H, Malyutina S, Ragino, Keogh R, Kudryavtsev AV, Govorun, Cook SA, Schirmer H, Eggen AE, Hopstock LA, Leon DA. Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage. . Journal of Epidemiology and Community Health. 2020en_US
dc.identifier.cristinIDFRIDAID 1820078
dc.identifier.doi10.1136/jech-2020-213885
dc.identifier.issn0143-005X
dc.identifier.issn1470-2738
dc.identifier.urihttps://hdl.handle.net/10037/20614
dc.language.isoengen_US
dc.publisherBMJen_US
dc.relation.ispartofIakunchykova, O. (2021). A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway. (Doctoral thesis). <a href=https://hdl.handle.net/10037/20633>https://hdl.handle.net/10037/20633</a>.
dc.relation.journalJournal of Epidemiology and Community Health
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEDREHELSE/289440/Norway/Healthy choices and the social gradient//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.titleWhy does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damageen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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