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dc.contributor.authorDragomir, Mihnea Paul
dc.contributor.authorMoisoiu, Vlad
dc.contributor.authorManaila, Roxana
dc.contributor.authorPardini, Barbara
dc.contributor.authorKnutsen, Erik
dc.contributor.authorAnfossi, Simone
dc.contributor.authorAmit, Moran
dc.contributor.authorCalin, George A.
dc.date.accessioned2021-03-01T21:56:29Z
dc.date.available2021-03-01T21:56:29Z
dc.date.issued2020-10-31
dc.description.abstractOne of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of this bidirectional approach has been the development of immunotherapy. Recently, a more complex landscape involving a multi-lateral communication between the non-malignant components of the TME started to emerge. A prime example is the interplay between immune and endothelial cells, which led to the approval of anti-vascular endothelial growth factor-therapy combined with immune checkpoint inhibitors and classical chemotherapy in non-small cell lung cancer. Hence, a paradigm shift approach is to characterize the crosstalk between different non-malignant components of the TME and understand their role in tumorigenesis. In this perspective, we discuss the interplay between nerves and immune cells within the TME. In particular, we focus on exosomes and microRNAs as a systemic, rapid and dynamic communication channel between tumor cells, nerves and immune cells contributing to cancer progression. Finally, we discuss how combinatorial therapies blocking this tumorigenic cross-talk could lead to improved outcomes for cancer patients.en_US
dc.identifier.citationDragomir, Moisoiu, Pardini, Knutsen, Anfossi, Amit, Calin. A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment. Journal of Clinical Medicine. 2020en_US
dc.identifier.cristinIDFRIDAID 1861894
dc.identifier.doi10.3390/jcm9113529
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/10037/20629
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalJournal of Clinical Medicine
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/825410/EU/Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response/ONCOBIOME/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleA Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironmenten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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