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dc.contributor.authorHansen, Merethe Selnes
dc.contributor.authorLicaj, Idlir
dc.contributor.authorBraaten, Tonje
dc.contributor.authorLund, Eiliv
dc.contributor.authorGram, Inger Torhild
dc.date.accessioned2021-04-15T08:35:56Z
dc.date.available2021-04-15T08:35:56Z
dc.date.issued2020-10-27
dc.description.abstract<i>Background</i> - We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.<br><br> <i>Methods</i> - We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between 1991 and 2007, through linkages to national registries through December 2015. We used Cox proportional hazards models, to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). We calculated PAF to indicate what proportion of lung cancer cases could have been prevented in the absence of smoking.<br><br> <i>Results</i> - During the more than 2.3 million person-years of observation, we ascertained 1507 lung cancer cases. Compared with never smokers, current (HR 13.88, 95% CI 10.18–18.91) smokers had significantly increased risk of lung cancer. Female never smokers exposed to passive smoking had a 1.3-fold (HR 1.34, 95% CI 0.89–2.01) non- significantly increased risk of lung cancer, compared with never smokers. The PAF of lung cancer was 85.3% (95% CI 80.0–89.2).<br><br> <i>Conclusion</i> - More than 8 in 10 lung cancer cases could have been avoided in Norway, if the women did not smoke.en_US
dc.identifier.citationHansen, Licaj, Braaten, Lund, Gram. The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study. British Journal of Cancer. 2020en_US
dc.identifier.cristinIDFRIDAID 1846476
dc.identifier.doi10.1038/s41416-020-01131-w
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/20884
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleThe fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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