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dc.contributor.authorSelven, Hallgeir
dc.contributor.authorRasmussen Busund, Lill-Tove
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorAndersen, Sigve
dc.contributor.authorKilvær, Thomas Karsten
dc.date.accessioned2021-07-01T13:12:08Z
dc.date.available2021-07-01T13:12:08Z
dc.date.issued2021-05-05
dc.description.abstractmiR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ hybridization and analyzed using digital pathology. To isolate the compartment specific contribution of miR-126, tumor and adjacent tumor stroma were considered separately. In univariate analyses, high expression of miR-126 in tumor and stroma was related to increased disease-specific survival (p < 0.001 and p = 0.005, respectively). In multivariate analyses, high miR-126 expression in tumor remained a significant independent predictor of improved disease-specific survival (HR = 0.42, CI 0.23–0.75, p = 0.004). Within different TNM-stages there was a tendency towards the same results, but with statistically significant results in stage II only (p = 0.007). High expression of miR-126 is an independent positive prognostic factor in stage I–III colon cancer. This finding may be used to identify patients in need of adjuvant chemotherapy.en_US
dc.identifier.citationSelven, Rasmussen Busund, Bremnes, Andersen, Kilvær. High expression of microRNA‑126 relates to favorable prognosis for colon cancer patients. Scientific Reports. 2021en_US
dc.identifier.cristinIDFRIDAID 1909106
dc.identifier.doi10.1038/s41598-021-87985-3
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/21662
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.ispartofSelven, H. (2023). Assessing new prognostic biomarkers in resected colon cancer patients. (Doctoral thesis). <a href=https://hdl.handle.net/10037/29356>https://hdl.handle.net/10037/29356</a>.
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleHigh expression of microRNA‑126 relates to favorable prognosis for colon cancer patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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