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dc.contributor.authorMoens, Ugo
dc.date.accessioned2010-01-04T10:11:24Z
dc.date.available2010-01-04T10:11:24Z
dc.date.issued2009-03-20
dc.description.abstractViruses are intracellular parasites that ensure their existence by converting host cells into viral particle producing entities or into hiding places rendering the virus invisible to the host immune system. Some viruses may also survive by transforming the infected cell into an immortal tumour cell. MicroRNAs are small non-coding transcripts that function as posttranscriptional regulators of gene expression. Viruses encode miRNAs that regulate expression of both cellular and viral genes, and contribute to the pathogenic properties of viruses. Hence, neutralizing the action of viral miRNAs expression by complementary single-stranded oligonucleotides or so-called anti-miRNAs may represent a strategy to combat viral infections and viral-induced pathogenesis. This review describes the miRNAs encoded by human viruses, and discusses the possible therapeutic applications of anti-miRNAs against viral diseases.en
dc.format.extent770072 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Biomedicine and Biotechnology, Volume 2009, Article ID 419539, 18 pagesen
dc.identifier.doidoi:10.1155/2009/419539
dc.identifier.issn1110-7243
dc.identifier.urihttps://hdl.handle.net/10037/2343
dc.identifier.urnURN:NBN:no-uit_munin_2093
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.titleSilencing Viral MicroRNA as a Novel Antiviral Therapy?en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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