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Impact of obesity-related inflammation on cardiac metabolism and function

Permanent lenke
https://hdl.handle.net/10037/24289
DOI
https://doi.org/10.12997/jla.2021.10.1.8
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Åpne
article.pdf (1.903Mb)
Publisert versjon (PDF)
Dato
2021-11-10
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Larsen, Terje; Jansen, Kirsten
Sammendrag
This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory adipokines and fatty acids (FAs). This condition, in turn, causes systemic inflammation and elevated FA concentrations in the circulation, which links obesity to several pathologies, including impaired insulin signaling in cardiac muscle and a subsequent shift in myocardial substrate oxidation in favor of FAs and reduced cardiac efficiency. This review also argues that efforts to prevent obesity-related cardiometabolic disease should focus on antiobesogenic strategies to restore normal adipose tissue metabolism.
Forlag
Korean Society of Lipidology and Atherosclerosis
Sitering
Larsen, Jansen. Impact of obesity-related inflammation on cardiac metabolism and function. Journal of Lipid and Atherosclerosis (JLA). 2021
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  • Artikler, rapporter og annet (medisinsk biologi) [1103]
Copyright 2021 The Korean Society of Lipid and Atherosclerosis

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