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dc.contributor.authorAljabri, Mohammad Belal
dc.contributor.authorLund, trine
dc.contributor.authorHøper, Anje Christina
dc.contributor.authorAndreasen, thomas vennØ
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorLindal, Sigurd
dc.contributor.authorYtrehus, Kirsti
dc.date.accessioned2022-06-27T10:30:28Z
dc.date.available2022-06-27T10:30:28Z
dc.date.issued2010-12-19
dc.description.abstractTo examine the response to chronic high-dose angiotensin II (Ang II) and a proposed milder response in female hearts with respect to gene expression and ischemic injury. Female and male litter–matched rats were treated with 400 ng kg<sup>-1</sup> min<sup>-1</sup> Ang II for 14 days. Hearts were isolated, subjected to 30-min ischemia and 30-min reperfusion in combination with functional monitoring and thereafter harvested for gene expression, WB and histology. Ang II-treated hearts showed signs of non-hypertrophic remodeling and had significantly higher end diastolic pressure after reperfusion, but no significant gender difference was detected. Ang II increased expression of genes related to heart function (ANF, &#946-MCH, Ankrd-1, PKC-&#945, PKC-&#948 TNF-&#945); fibrosis (Col I-&#945 1, Col III-&#945 1, Fn-1, Timp1) and apoptosis (P53, Casp-3) without changing heart weight but with 68% increase in collagen content. High (sub-toxic) dose of Ang II resulted in marked heart remodeling and diastolic dysfunction after ischemia without significant myocyte hypertrophy or ventricular chamber dilatation. Although there were some gender-dependent differences in gene expression, female gender did not protect against the overall response.en_US
dc.identifier.citationAljabri M B, Lund t, Høper AC, Andreasen tv, Al-Saad S, Lindal S, Ytrehus k. Gene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin II. Cardiovascular Toxicology. 2011;11(1):38-47en_US
dc.identifier.cristinIDFRIDAID 828271
dc.identifier.doi10.1007/s12012-010-9100-0
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.urihttps://hdl.handle.net/10037/25576
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCardiovascular Toxicology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2010 The Author(s)en_US
dc.titleGene Expression, Function and Ischemia Tolerance in Male and Female Rat Hearts After Sub-Toxic Levels of Angiotensin IIen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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