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dc.contributor.authorMostowy, Serge
dc.contributor.authorSancho-Shimizu, Vanessa
dc.contributor.authorHamon, Mélanie Anne
dc.contributor.authorSimeone, Roxane
dc.contributor.authorBrosch, Roland
dc.contributor.authorJohansen, Terje
dc.contributor.authorCossart, Pascale
dc.date.accessioned2022-09-20T12:20:54Z
dc.date.available2022-09-20T12:20:54Z
dc.date.issued2011-06-06
dc.description.abstractAutophagy is an important mechanism of innate immune defense. We have recently shown that autophagy components are recruited with septins, a new and increasingly characterized cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin. On the other hand, intracytosolic Listeria avoids autophagy recognition by expressing ActA, a bacterial effector required for actin polymerization. Here, we exploit Shigella and Listeria as intracytosolic tools to characterize different pathways of selective autophagy. We show that the ubiquitin-binding adaptor proteins p62 and NDP52 target Shigella to an autophagy pathway dependent upon septin and actin. In contrast, p62 or NDP52 targets the Listeria ActA mutant to an autophagy pathway independent of septin or actin. TNF- , a host cytokine produced upon bacterial infection, stimulates p62-mediated autophagic activity and restricts the survival of Shigella and the Listeria ActA mutant. These data provide a new molecular framework to understand the emerging complexity of autophagy and its ability to achieve specific clearance of intracytosolic bacteria.en_US
dc.identifier.citationMostowy S, Sancho-Shimizu, Hamon, Simeone, Brosch, Johansen T, Cossart. p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways. Journal of Biological Chemistry. 2011;286(30):26987-26995en_US
dc.identifier.cristinIDFRIDAID 848693
dc.identifier.doi10.1074/jbc.M111.223610
dc.identifier.issn0021-9258
dc.identifier.issn1083-351X
dc.identifier.urihttps://hdl.handle.net/10037/26874
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Biological Chemistry
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/233348/EU/Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology/MODELIST/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2011 The American Society for Biochemistry and Molecular Biologyen_US
dc.titlep62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathwaysen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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