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dc.contributor.authorTadesse, Margey
dc.contributor.authorGulliksen, Bjørn
dc.contributor.authorStrøm, Morten B.
dc.contributor.authorStyrvold, Olaf B.
dc.contributor.authorHaug, Tor
dc.date.accessioned2010-10-08T12:09:44Z
dc.date.available2010-10-08T12:09:44Z
dc.date.issued2008-06-18
dc.description.abstractBenthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). After separation into an ACN-rich phase (ACN extract) and an aqueous phase, and subsequent solid phase extraction of the aqueous phase, fractions differing in polarity were obtained and screened for antibacterial and antifungal activities, along with the more lipophilic ACN-extracts. Antimicrobial activity was determined against two Gram-negative, two Gram-positive bacteria, and two strains of fungi. Notably, all the invertebrate species in the study showed activity against all four strains of bacteria and the two strains of fungi. In general, the aqueous fractions displayed highest antimicrobial activity, and the most potent extracts were obtained from the colonial ascidian Synoicum pulmonaria which displayed activity against bacteria and fungi at a concentration of 0.02 mg/ml; the lowest concentration tested.en
dc.descriptionThis is the accepted manuscript version of the article. Reprinted with permission. Published version is available at <a href=http://dx.doi.org/10.1016/j.jip.2008.06.009>http://dx.doi.org/10.1016/j.jip.2008.06.009</a> <br>The published version of this article is part of Margey Tasesse's doctoral thesis, which is available at <a href=http://hdl.handle.net/10037/2702>http://hdl.handle.net/10037/2702</a>en
dc.format.extent2520461 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationJournal of Invertebrate Pathology, 99(2008), 286-293en
dc.identifier.issn0022-2011
dc.identifier.urihttps://hdl.handle.net/10037/2728
dc.identifier.urnURN:NBN:no-uit_munin_2471
dc.language.isoengen
dc.publisherElsevieren
dc.rights.accessRightsopenAccess
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448en
dc.subjectantimicrobial screeningen
dc.subjectmarine bioprospectingen
dc.subjectnatural productsen
dc.subjectspongesen
dc.subjectSynoicum pulmonariaen
dc.subjecttunicatesen
dc.titleScreening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norwayen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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