Viser treff 256-275 av 290

    • Studies of ionospheric parameters by means of electron plasma lines observed by EISCAT 

      Guio, Patrick (Doctoral thesis; Doktorgradsavhandling, 1998-12-18)
      This work presents a study of the electron plasma lines observed by the incoherent scatter radar EISCAT. The work is focusing on two parts. On one hand, the design of a plasma line experiment for the EISCAT system with an improved spatial resolution. On the other hand, the comparison of the plasma line data collected with the EISCAT radar with an improved model for the intensity and the Doppler ...
    • Studies on selectivity determinants of protein kinase inhibitor binding 

      Alam, Kazi Asraful (Doctoral thesis; Doktorgradsavhandling, 2017-06-09)
      Protein kinases are involved in many essential cellular processes, and are regulated in a dynamic manner by the movement of domains or motifs via interaction with various proteins and substrates. Protein kinase deregulation can lead to a variety of diseases, including cancer and diabetes. Protein kinase A (PKA) has been a prototype to study the entire family, including for studies in drug discovery ...
    • Studying usage and experiences of mHealth technology for its improved usability - Mixed methods research for understanding users’ long-term engagement with the Few Touch application for self-management of Type 2 diabetes mellitus - 

      Tatara, Naoe (Doctoral thesis; Doktorgradsavhandling, 2014-02-28)
      In spite of a number of mHealth (use of mobile computing for health care) studies targeting people with diabetes, there has not yet been any clear evidence of its effect. Due to obscurity regarding subjects’ engagement with each component of the provided technology, it is not clear which factors are important and why. Considering that behavior change is a path of improvement in self-management of ...
    • Sub-seabed fluid-flow systems and gas hydrates of the SW Barents Sea and North Sea margins 

      Vadakkepuliyambatta, Sunil (Doctoral thesis; Doktorgradsavhandling, 2014-04-25)
      Denne avhandlingen omfatter studier av utbredelse og evolusjon av fluid migrasjonssystemer og gasshydrater i SV Barentshavet og nordlige Nordsjøen. Avhandlingen er basert på tolkning av seismiske og brønndata og numerisk modelling av hydratstabiliteten. Store fluid lekkasjestrukturer forekommer i SV Barentshavet og viser kobling mot de store tektoniske forkastningssytemene. Det er trolig istidene ...
    • Subglacial hydrology of the Fennoscandian and Barents Sea ice sheets 

      Shackleton, Calvin (Doctoral thesis; Doktorgradsavhandling, 2019-06-11)
      The drainage of meltwater beneath ice sheets exerts a fundamental control on ice flow variability, by regulating the lubrication of the ice-bed interface, and determining subglacial sediment shear strengths. This thesis investigates meltwater drainage of the Fennoscandian and Barents Sea ice sheets through the combined application of geomorphologically based reconstruction and modelling of subglacial ...
    • Super-resolution histology 

      Villegas-Hernández, Luis Enrique (Doctoral thesis; Doktorgradsavhandling, 2023-12-05)
      <p>Super-resolution optical microscopy (SRM) holds great promise for the advancement of life sciences, unlocking the secrets of the minute machinery composing living organisms. While broadly accepted in cell biology, the existing SRM methods haven’t effectively breached relevant fields such as histological practice, mainly due to the complexity, elevated costs, limited throughput, and incompatibility ...
    • Surface properties tune thermal adaptation of enzymes - Computational studies of endonuclease A 

      Michetti, Davide (Doctoral thesis; Doktorgradsavhandling, 2017-04-26)
      The endonucleases A from Aliivibrio salmonicida (VsEndA, cold-adapted) and Vibrio cholerae (VcEndA, warm-adapted) have been studied in this work. The goal was to compare these two systems, in order to find structural differences that could explain the mechanism of cold adaptation in the psychrophilic EndA. These two enzymes have previously been studied experimentally and the crystal structures have ...
    • Synthesis and inhibitor design of carbapenemase inhibitors 

      Akhter, Sundus (Doctoral thesis; Doktorgradsavhandling, 2018-05-24)
      The efficiency of bacteria in acquiring resistance for their survival ensures a never-ending war against resistance. The only tactic to curtail the resistance crisis is to keep pace with it, e.g. by continuous development of new antibiotics with activity against resistant bacteria or revival of existing agents by inhibiting the mechanisms of resistance. β-lactams are the largest and most widely used ...
    • Synthesis of a novel class of antitubercular peptidomimetics based on β-aminoboronates. 

      Gorovoy, Alexey (Doctoral thesis; Doktorgradsavhandling, 2012-11-16)
      The unique properties of antimicrobial peptides have attracted the attention of chemists since the 1970’s. This class of compounds provides additional tools in the treatment of infections and the work described in this thesis was therefore focused on the synthesis of short peptidomimetics on the basis of modified amino acids and evaluation of their antimicrobial activity. The compounds of choice ...
    • Synthesis of Sterically Hindered Macrocyclic Ligands via Demetalation of Metallocorroles 

      Capar, Jan (Doctoral thesis; Doktorgradsavhandling, 2016-06-07)
      Despite important developments in synthetic corrole chemistry, the field has long been handicapped by the lack of procedures for demetalation of metallocorroles. This thesis presents general demetalation methods for metallocorroles. A reductive demetalation method was developed using concentrated H2SO4 with 5-200 equivalent of FeCl2 or SnCl2 as a reducing agent. The method proved to be quite general ...
    • Synthetic aperture ultrasound imaging with application to interior pipe inspection 

      Skjelvareid, Martin Hansen (Doctoral thesis; Doktorgradsavhandling, 2012-09-07)
      This thesis is concerned with synthetic aperture focusing of ultrasonic pulse-echo measurements, with application to multilayered media and cylindrical structures. The work is motivated by the need for accurate methods for non-destructive testing of pipelines, particularly water distribution pipelines. By improving the lateral resolution in ultrasonic measurements, the synthetic aperture algorithms ...
    • Theoretical studies of natural and electromagnetically induced birefringences 

      Shcherbin, Dmitry (Doctoral thesis; Doktorgradsavhandling, 2011-06-01)
    • Theoretical studies of natural and magnetic circular dichroism 

      Solheim, Harald (Doctoral thesis; Doktorgradsavhandling, 2011-06-23)
      This dissertation presents theoretical studies mainly of natural and magnetic circular dichroism spectra. For magnetic circular dichroism, the importance of electron correlation effects, here included at the density-functional functional level of theory, and solvent effects are discussed, both being shown to have significant impact on the final spectra. In addition, a unified approach for calculating ...
    • Time-frequency characterization of harmonizable random processes 

      Hindberg, Heidi (Doctoral thesis; Doktorgradsavhandling, 2009)
      In this thesis we study how to characterize nonstationary harmonizable random processes simultaneously in time and frequency. Unlike stationary random processes, harmonizable processes can have a frequency content that changes with time. Rather than working directly with the process itself, we analyze the second-order moment functions of the process and characterize the process from these moments. ...
    • Toward a Collaborative Platform for Hybrid Designs Sharing a Common Cohort 

      Arnes, Jo Inge (Doctoral thesis; Doktorgradsavhandling, 2024-01-18)
      <p>This doctoral thesis binds together four included papers in a thematical whole and is simultaneously an independent work proposing a platform facilitating epidemiological research. <p><i>Population-based prospective cohort studies</i> typically recruit a relatively large group of participants representative of a studied population and follow them over years or decades. This group of participants ...
    • Toward Reproducible Analysis and Exploration of High-Throughput Biological Datasets 

      Fjukstad, Bjørn (Doctoral thesis; Doktorgradsavhandling, 2019-01-21)
      This dissertation argues that we can develop unified systems for reproducible exploration and analysis of high-throughput biological datasets. We propose an approach, Small Modular Entities (SME), that orchestrates the execution of analysis pipelines and data exploration applications. We realize SMEs using software container technologies together with well-defined interfaces, configuration, and ...
    • Towards Enantioselective Carboxylation and Hydrogenation Reactions (Quantum Chemical Modelling of Homogeneous Reactions) 

      Pavlovic, Ljiljana (Doctoral thesis; Doktorgradsavhandling, 2020-08-21)
      With the aid of DFT methods, it is possible to get insights into the mechanistic details of homogeneous reactions, the substrate preferences and activities of catalysts. Computational methods can also help to identify the selectivity-determining factors that govern asymmetric reactions. In this thesis, DFT methods are applied in order to study the enantioselective addition of small molecules, such ...
    • Towards Interpretable, Trustworthy and Reliable AI 

      Gautam, Srishti (Doctoral thesis; Doktorgradsavhandling, 2024-03-15)
      <p>The field of artificial intelligence recently witnessed remarkable growth, leading to the development of complex deep learning models that perform exceptionally across various domains. However, these developments bring forth critical issues. Deep learning models are vulnerable to inheriting and potentially exacerbating biases present in their training data. Moreover, the complexity of these models ...
    • Trends and variability of polar mesopause region temperatures attributed to atmospheric dynamics and solar activity 

      Holmen, Silje Eriksen (Doctoral thesis; Doktorgradsavhandling, 2016-12-19)
      The mesopause region can be considered a "boundary region" between the neutral atmosphere, where atmospheric constituents and momentum are transported mainly by winds and turbulent eddies, and the ionosphere, where the main transport mechanism is molecular diffusion. In the mesopause, complex interactions between dynamics and photochemistry occur, and we are far from a complete understanding of these ...
    • Two approaches to novel anticancer agents. Small-molecule library synthesis and evaluation 

      Boomgaren, Marc (Doctoral thesis; Doktorgradsavhandling, 2020-03-06)
      <p>The work presented in this dissertation combines two fully independent approaches to achieve compound libraries for anticancer drug research. <p>Project 1: Development of compounds inhibiting human dUTPase as an amplifier of a thymidylate synthase inhibitor based cancer therapy <p>The human dUTPase has received increased attention as a drug target in the recent years. Its inhibition can ...