<b>Context:</b> Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two of the three major components: hypoparathyroidism, primary adrenocortical insuffi- ciency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up of APS1 is sparse. <b>Objective:</b> To describe the phenotypes of APS1 and correlate the ...

Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). Macrophages are particularly abundant in the porcine lung circulation. Upon bradykinin binding macrophages release cytokines and endothelial ...

While there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose.As the gold standardmethod for GFR determination, urinary (or renal) clearance of inulin, fades into the background due to inconvenience and high cost, a diversity of filtrationmarkers and protocols compete to ...

Background: Recent studies have suggested that catheterdirected thrombolysis (CDT) reduces development of postthrombotic syndrome (PTS). Ultrasound-assisted CDT (USCDT) might enhance the efficiency of thrombolysis. We aimed to compare USCDT with CDT on efficacy, safety, development of PTS, and quality of life after longterm follow-up. <p>Methods: We describe a retrospective case series of 94 ...

Background Cluster headache (CH) is regarded as a chronobiological disorder. The hypothalamic biological clock may thus be involved in the pathophysiology, but few studies have actually investigated this in CH patients. A variable number tandem repeat (VNTR) polymorphism of the PER3 clock gene has been associated to preferred daily rhythm (chronotype) in several studies. We aimed to study the ...

Objective: To determine whether a treatment strategy based on structured ultrasound assessment would lead to improved outcomes in rheumatoid arthritis, compared with a conventional strategy. <p>Design: Multicentre, open label, two arm, parallel group, randomised controlled strategy trial. <p>Setting: Ten rheumatology departments and one specialist centre in Norway, from September 2010 to ...

Background: Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship ...

Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence ...

The concept of ‘self’ has a pivotal role in psychotic symptoms (Conrad, 1958), but its utility in the treatment process has been limited. Since perceptions of ‘self’ – and of ‘others’ – change as symptoms evolve and resolve (Parnas andHandest, 2003), if appropriately assayed this concept provides a unique entry-point through which the congruity between delusions and illness can be examined. The ...

<b>Objective:</b> The epidemiology of hypoparathyroidism (HP) is largely unknown. We aimed to determine prevalence, etiologies, health related quality of life (HRQOL) and treatment pattern of HP.<br> <b>Methods:</b> Patients with HP and 22q11 deletion syndrome (DiGeorge syndrome) were identified in electronic hospital registries. All identified patients were invited to participate in a survey. ...