Institutt for klinisk medisin: Nye registreringer

Viser treff 1521-1540 av 1974

    • Use of social media for sexual health promotion: a scoping review 

      Gabarron, Elia; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-19)
      <b>Background: </b> <br> In order to prevent sexually transmitted infections (STIs), the World Health Organization recommends educating people on sexual health. With more than 2 billion active users worldwide, online social media potentially represent powerful channels for health promotion, including sexual health. <br> <b>Objective: </b> <br> To review the scientific literature on the use of ...

    • CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in Granulomatosis with polyangiitis patients 

      Besada, Emilio; Nossent, Johannes C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)
      <b>Introduction</b> <br> Rituximab (RTX) is a B cell-depleting agent approved for the treatment of granulomatosis with polyangiitis (GPA). RTX reduces antibody producing precursor plasma cells and inhibits B and T cells interaction. Infections related to T cell immunodeficiency are not infrequent during RTX treatment. Our study investigated CD4 cell count and CD4/CD8 ratio in GPA patients during the ...

    • Arm Crank and Wheelchair Ergometry Produce Similar Peak Oxygen Uptake but Different Work Economy Values in Individuals with Spinal Cord Injury 

      Tørhaug, Tom; Brurok, Berit; Hoff, Jan; Helgerud, Jan; Leivseth, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-20)
      <i>Objective. </i> To study whether values for peak oxygen uptake (VO<sub>2peak</sub>) and work economy (WE) at a standardized workload are different when tested by arm crank ergometry (ACE) and wheelchair ergometry (WCE). <i>Methods. </i> Twelve paraplegic men with spinal cord injury (SCI) in stable neurological condition participated in this cross-sectional repeated-measures study. We determined ...

    • Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis 

      Hestad, Knut A.; Engedal, Knut; Whist, Jon Elling; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-13)
      INTRODUCTION: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as ...

    • Targets of Wnt/ß-Catenin Transcription in Penile Carcinoma 

      Arya, Manit; Thrasivoulou, Christopher; Henrique, Rui; Millar, Michael; Hamblin, Ruth; Davda, Reena; Aare, Kristina; Masters, John R.; Thomson, Calum; Muneer, Asif; Patel, Hitendra R.H.; Ahmed, Aamir (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-22)
      Penile squamous cell carcinoma (PeCa) is a rare malignancy and little is known regarding the molecular mechanisms involved in carcinogenesis of PeCa. The Wnt signaling pathway, with the transcription activator ß-catenin as a major transducer, is a key cellular pathway during development and in disease, particularly cancer. We have used PeCa tissue arrays and multi-fluorophore labelled, quantitative, ...

    • Evaluation of satisfaction with care in a midwifery unit and an obstetric unit: a randomized controlled trial of low-risk women 

      Bernitz, Stine; Øian, Pål; Sandvik, Leiv; Blix, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-18)
      BACKGROUND Satisfaction with birth care is part of quality assessment of care. The aim of this study was to investigate possible differences in satisfaction with intrapartum care among low-risk women, randomized to a midwifery unit or to an obstetric unit within the same hospital. METHODS Randomized controlled trial conducted at the Department of Obstetrics and Gynecology, Østfold Hospital ...

    • Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite 

      Sibille, Kimberly T; Steingrímsdóttir, Ólöf Anna; Fillingim, Roger B; Stubhaug, Audun; Schirmer, Henrik; Chen, Huaihou (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-17)
      BACKGROUND. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. OBJECTIVES. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. METHODS. Data from 12,982 participants in the 6th Tromsø ...

    • Health Economics and Radium-223 (Xofigo®) in the Treatment of Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Case History and a Systematic Review of the Literature 

      Norum, Jan; Traasdahl, Erik R.; Totth, Arpad; Nieder, Carsten; Olsen, Jan Abel (Journal article; Peer reviewed; Tidsskriftartikkel, 2015)
      OBJECTIVES: Prostate cancer (PC) is the most common cancer in Western countries. Recent advances in the treatment of metastatic castration resistant prostate cancer (mCRPC) have caused significant pressure on health care budgets. We aimed to exemplify this dilemma presenting an example, radium-223 (Xofigo®), and review the literature. METHODS: A 74-year-old man diagnosed with mCRPC was referred ...

    • Red cell distribution width is associated with future risk of incident stroke. The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Skjelbakken, Tove; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)
      Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth ...

    • Red cell distribution width and carotid atherosclerosis progression: The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Vik, Anders; Skjelbakken, Tove; Brox, Jan; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-29)
      Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey ...

    • Ethical Issues of Social Media Usage in Healthcare 

      Denecke, Kerstin; Bamidis, Panagiotis D.; Bond, Carol; Gabarron, Elia; Househ, M; Lau, A. Y. S.; Mayer, Miguel A.; Merolli, Mark; Hansen, Margareth (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-13)
      OBJECTIVE: Social media, web and mobile technologies are increasingly used in healthcare and directly support patientcentered care. Patients benefit from disease self-management tools, contact to others, and closer monitoring. Researchers study drug efficiency, or recruit patients for clinical studies via these technologies. However, low communication barriers in socialmedia, limited privacy and ...

    • Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: The Tromsø study 

      Lerstad, Gunhild; Enga, Kristin Fjeldstad; Jorde, Rolf; Brodin, Ellen Elisabeth; Svartberg, Johan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-21)
      Objective: The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. Design: Population-based cohort study. Methods: TSH was measured in 11 962 subjects aged 25–89 years who participated in Tromsø 4–6 starting in ...

    • Nytt legemiddel for å hindre tilbakefall av blodpropp? 

      Hindberg, Kristian (Others; Andre, 2015-11-27)
      I en ny studie, utført i flere europeiske land, er det undersøkt om legemiddelet Sulodexide kan forebygge at man får en ny blodpropp etter å først ha fått én. Etter at man har fått en blodpropp vil man få behandling med blodfortynnende medisin. For noen pasienter er dessverre risikoen for indre blødninger for stor med denne behandlingen, og behandlingen blir derfor avsluttet etter 3-12 måneder. Det ...

    • Involuntary psychiatric admission: how the patients are detected and the general practitioners' expectations for hospitalization. An interview-based study 

      Røtvold, Ketil; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-08)
      <p>Background: In Norway, it is usually GPs that refer patients to involuntary admission. A high proportion of such referrals come from out-of-hours clinics. Little is known about who first initiate the contact between the patients and the referring doctors and which expectations the referring doctors have with respect to the involuntary admissions. The aim of the study was to examine who first ...

    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...

    • How Do Elderly Poor Prognosis Patients Tolerate Palliative Concurrent Chemoradiotherapy for Locally Advanced NoneSmall Cell Lung Cancer Stage III? A Subset Analysis From a Clinical Phase III Trial 

      Strøm, Hans Henrik; Bremnes, Roy M.; Sundstrøm, Stein Harald; Helbekkmo, Nina; Aasebø, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05)
      In a phase III trial of patients with unresectable stage III nonesmall-cell lung cancer and a poor prognosis, palliative concurrent chemoradiotherapy (CRT) provided a significantly better outcome than chemotherapy alone, except among performance status 2 patients. The results of the present exploratory subgroup analysis indicate that elderly patients with poor prognosis can also experience ...

    • Fatal injuries in rural and urban areas in northern Finland: a 5-year retrospective study 

      Raatiniemi, Lasse; Steinvik, Tine; Liisanantti, Janne; Ohtonen, Pasi; Martikainen, Matti; Alahuhta, Seppo; Dehli, Trond; Wisborg, Torben; Bakke, Håkon Kvåle (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-08)
      Background: Finland has the fourth highest injury mortality rate in the European Union. To better understand the causes of the high injury rate, and prevent these fatal injuries, studies are needed. Therefore, we set out to complete an analysis of the epidemiology of fatal trauma, and any contributory role for alcohol, long suspected to promote fatal injuries. As a study area, we chose the ...

    • Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome 

      Volokhina, Elena B.; van de Kar, Nicole C.A.J.; Bergseth, Grethe; van der Velden, Thea J.A.M.; Westra, Dineke; Wetzels, Jack F.M.; van den Heuvel, Lambertus P.; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-23)
      Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition monitoring in these patients has not been standardized. In this study we evaluated novel functional assays for application in routine follow-up. We documented that the Wieslab® complement screen assay showed a sensitivity of 1–2% of C5 activity ...

    • The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis 

      Hovland, Anders; Jonasson, Lena; Garred, Peter; Yndestad, Arne; Aukrust, Pål; Lappegård, Knut Tore; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)
      Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier research focus on adaptive immunity has gradually switched towards the role of innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between them, ...

    • Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn 

      Hallstensen, Randi; Bergseth, Grete; Foss, Stian; Jæger, Steinar; Gedde-Dahl, Thobias; Holt, jan; Christiansen, Dorte; Lau, Corinna; Brekke, Ole Lars; Armstrong, Elina; Stefanovic, Vedran; Andersen, Jan Terje; Sandlie, Inger; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-13)
      Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether or not the complement activity in newborns from pregnant women who receive eculizumab is impaired. A novel eculizumab-C5 complex (E-C5) specific assay was developed and ...