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dc.contributor.authorJarholm, Jonas Alexander
dc.contributor.authorBjørnerud, Atle
dc.contributor.authorDalaker, Turi Olene
dc.contributor.authorAkhavi, Mehdi Sadat
dc.contributor.authorKirsebom, Bjørn-Eivind
dc.contributor.authorPålhaugen, Lene
dc.contributor.authorNordengen, Kaja
dc.contributor.authorGrøntvedt, Gøril Rolfseng
dc.contributor.authorNakling, Arne Exner
dc.contributor.authorKalheim, Lisa Flem
dc.contributor.authorAlmdahl, Ina Selseth
dc.contributor.authorTeceläo, Sandra Raquel Ramos
dc.contributor.authorFladby, Tormod
dc.contributor.authorSelnes, Per
dc.description.abstractBackground: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. <p>Methods: We used Automatic Segmentation of Hippocampal Subfields (ASHS) to determine MTL morphometry from MRI. We harmonized scanner effects using the recently developed longitudinal ComBat. Subjects were classified according to the A/T/N system, and as normal controls (NC), subjective cognitive decline (SCD), or mild cognitive impairment (MCI). Positive or negative values of A, T, and N were determined by cerebrospinal fluid measurements of the Aβ<sub>42/40</sub> ratio, phosphorylated and total tau. From 406 included subjects, longitudinal data was available for 206 subjects by stage, and 212 subjects by A/T/N. Results: Compared to A–/T–/N– at baseline, the entorhinal cortex, anterior and posterior hippocampus were smaller in A+/T+orN+. Compared to NC A– at baseline, these subregions were also smaller in MCI A+. Longitudinally, SCD A+ and MCI A+, and A+/T–/N– and A+/T+orN+, had significantly greater atrophy compared to controls in both anterior and posterior hippocampus. In the entorhinal and parahippocampal cortices, longitudinal atrophy was observed only in MCI A+ compared to NC A–, and in A+/T–/N– and A+/T+orN+ compared to A–/T–/N–. <p>Conclusion: We found MTL neurodegeneration largely consistent with existing models, suggesting that harmonized MRI volumetry may be used under conditions that are common in clinical multi-center cohorts.en_US
dc.identifier.citationJarholm, Bjørnerud, Dalaker, Akhavi, Kirsebom, Pålhaugen, Nordengen, Grøntvedt, Nakling, Kalheim, Almdahl, Teceläo S, Fladby, Selnes. Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort. Journal of Alzheimer's Disease. 2023;94(1):259-279en_US
dc.identifier.cristinIDFRIDAID 2169519
dc.publisherIOP Pressen_US
dc.relation.journalJournal of Alzheimer's Disease
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleMedial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohorten_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US

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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)