LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons

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https://hdl.handle.net/10037/33181
DOI
https://doi.org/10.1083/jcb.202303008
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Date
2023-04-10
Type
Journal article
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Author
Kournoutis, Athanasios; Johansen, Terje
Abstract
It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jimenez-Moreno et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.201910133) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for LMX1B-mediated transcription of autophagy genes, providing stress protection and ensuring survival of midbrain dopaminergic neurons.
Is part of
Kournoutis, A. (2024). ATG8s in the nucleus: Beyond the autophagy paradigm. (Doctoral thesis). https://hdl.handle.net/10037/33481.
Publisher
Rockefeller University Press
Citation
Kournoutis A, Johansen T. LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons. Journal of Cell Biology. 2023
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