Browsing Institutt for medisinsk biologi by Title

Now showing items 797-816 of 1144

    • Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field 

      Moens, Ugo; Passerini, Sara; Falquet, Mar; Sveinbjørnsson, Baldur; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)
      Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in ...

    • Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation 

      Kumar, Suresh; Gu, Yuexi; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Jain, Ashish; Farzam, Farzin; Mudd, Michal H.; Anonsen, Jan Haug; Rusten, Tor Erik; Kasof, Gary; Ktistakis, Nicholas; Lidke, Keith A; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-28)
      Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the ATG13<sup>+</sup>FIP200<sup>+</sup> mammalian pre-autophagosomal structure (mPAS) in response to induction of autophagy. TBK1 phosphorylates Stx17 ...

    • Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity 

      Wirth, Martina; Mouilleron, Stephane; Zhang, Wenxin; Abudu, Yakubu Princely; Jain, Ashish; Olsvik, Hallvard Lauritz; Bruun, Jack-Ansgar; Razi, Minoo; Jefferies, Harold B.J.; Lee, Rebecca; Joshi, Dhira; O'Reilly, Nicola; Johansen, Terje; Tooze, Sharon A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      <p>Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration. Autophagy-related 8 (ATG8) proteins play a central role in autophagosome formation and selective delivery of cytoplasmic cargo to lysosomes by recruiting autophagy adaptors and receptors. The LC3-interacting region (LIR) docking site (LDS) of ...

    • A Phylogenetic Study of SPBP and RAI1: Evolutionary Conservation of Chromatin Binding Modules 

      Darvekar, Sagar; Rekdal, Cecilie; Johansen, Terje; Sjøttem, Eva (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Our genome is assembled into and array of highly dynamic nucleosome structures allowing spatial and temporal access to DNA. The nucleosomes are subject to a wide array of post-translational modifications, altering the DNAhistone interaction and serving as docking sites for proteins exhibiting effector or “reader” modules. The nuclear proteins SPBP and RAI1 are composed of several putative “reader” ...

    • Physical activity and bone : the importance of the various mechanical stimuli for bone mineral density : a review 

      Morseth, Bente; Emaus, Nina; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Numerous studies have reported benefits of regular physical activity on bone mineral density (BMD). The effects of physical activity on BMD are primarily linked to the mechanisms of mechanical loading, but the understanding of the precise mechanism behind the association is incomplete. The aim of this paper was to review the main findings concerning sources and types of mechanical stimuli in relation ...

    • Physical activity and cardiovascular risk factors in a 40- to 42-year-old rural Norwegian population from 1975–2010: repeated cross-sectional surveys 

      Solbraa, Ane; Holme, Ingar Morten K; Graff-Iversen, Sidsel; Resaland, Geir Kåre; Aadland, Eivind; Anderssen, Sigmund Alfred (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: Geographical differences in cardiovascular diseases (CVD) have been observed among Norwegian counties. Better long-term health status and higher physical activity (PA) levels have been documented in the county of Sogn & Fjordane compared with other counties. However, recent trends in CVD risk factors have not been documented. The aim of this study was to investigate the secular trends ...

    • Physical activity and mortality among Norwegian women : the Norwegian Women and Cancer Study 

      Borch, Kristin Benjaminsen; Braaten, Tonje; Lund, Eiliv; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Physical activity (PA) and its relationship with all-cause mortality suggest a strong and consistent inverse association. This study prospectively investigated the association between PA level and mortality among participants of the Norwegian Women and Cancer (NOWAC) Study. A total of 66,136 NOWAC participants were followed-up until December 31st 2008. PA level and possible confounding factors ...

    • Physical activity and the risk of postmenopausal breast cancer - The Norwegian Women and Cancer Study 

      Borch, Kristin Benjaminsen; Lund, Eiliv; Braaten, Tonje; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Physicians' messages in problematic sickness certification : a narrative analysis of case reports 

      Engblom, Monika; Alexanderson, Kristina; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Many physicians find sickness certification tasks problematic. There is some knowledge about situations that are experienced as problematic, whereas less is understood about how physicians respond to the problems they face. One way to acquire such knowledge is to consider “reflection-in-action”, aspects of which are expressed in the physician’s interpretation of the patient’s story. The aim of this ...

    • Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort 

      Olsen, Karina Standahl; Fenton, Christopher Graham; Frøyland, Livar; Waaseth, Marit; Paulssen, Ruth H; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      High blood concentrations of n-6 fatty acids (FAs) relative to n-3 FAs may lead to a “physiological switch” towards permanent low-grade inflammation, potentially influencing the onset of cardiovascular and inflammatory diseases, as well as cancer. To explore the potential effects of FA ratios prior to disease onset, we measured blood gene expression profiles and plasma FA ratios (linoleic ...

    • Plasma levels of apolipoprotein-E in residents of the European North of Russia 

      Kaneva, Anastasiya M.; Bojko, Evgeny; Potolitsyna, Natalya N.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Apolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fact that specific features of lipid metabolism in the northerners are described. The present work was designed to study plasma levels of apoE in residents of the European North ...

    • Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) 

      Nitter, Mathilde Hjelle; Norgård, Benedicte Wentzel; De Vogel, Stefan; Eussen, Simone; Meyer, Klaus; Ulvik, Arve; Ueland, Per Magne; Nygård, Ottar; Vollset, Stein Emil; Bjørge, Tone; Tjønneland, Anne; Hansen, Louise; Boutron-Ruault, Marie-Christine; Racine, Antoine; Cottet, Vanessa; Kaaks, Rudolf; Kühn, Tilman; Trichopoulou, Antonia; Bamia, Christina; Naska, Androniki; Grioni, Sara; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquita, H. Bas; Van Kranen, Henk J.; Peeters, Petra H. M.; Weiderpass, Elisabete; Dorronsoro, Miren; Jakszyn, Paula; Sánchez, María-José; Argüelles, Marcial Vicente; Huerta, José-Maria; Barricarte, Aurelio; Johansson, Matthias; Ljuslinder, Ingrid; Khaw, Kay Tee; Wareham, Nicholas J.; Freisling, Heinz; Duarte-Salles, Talita; Stepien, Magdalena; Gunter, Mark J.; Riboli, Élio B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study 

      Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Aune, Dagfinn; Naccarati, Alessio; Panico, Salavatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-De-Mesquita, Hendrik Bastiaan; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Quirõs, Jose Ramõn; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-12)
      Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subsequent PDAC risk. A panel of eight miRs (miR-10a, -10b, -21-3p, -21-5p, -30c, -106b, ...

    • Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months 

      Jorde, Rolf; Svartberg, Johan; Joakimsen, Ragnar Martin; Coucheron, Dag-Hugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-05-17)
      Background: Recently a large number of short non-coding-RNAs (microRNAs, (miRNA)) have been identified. These miRNAs act as post-transcriptional regulators where they generally have an inhibitory function. miRNAs are present in all human cells, and they are also detected in serum or plasma. The miRNAs have a broad range of actions, and their biogenesis must therefore be under tight control. One ...

    • Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion? 

      Nedberg, Nora Hersoug; Turowski, Gitta Erika; Guz, Katarzyna; Przytuła, Ewa; Uhrynowska, Małgorzata; Roald, Borghild; Husebekk, Anne; Sitras, Vasilis; Nystad, Mona; Dębska, Marzena; Brojer, Ewa; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      <i>Introduction</i> - Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic ...

    • Political Manipulation in Human Rights Violations: A Case of Honor Killings in Balochistan, Pakistan 

      Khalil, Noor Akbar; Sheikh, Mashhood Ahmed (Journal article; Tidsskriftartikkel, 2010)

    • Polyphyletic origin of the genus Physarum (Physarales, Myxomycetes) revealed by nuclear rDNA mini-chromosomal analysis and group I intron synapomorphy 

      Nandipati, Satish C R; Haugli, Kari B.; Coucheron, Dag-Hugo; Haskins, Edward F.; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-08-31)
      Physarales represents the largest taxonomic order among the plasmodial slime molds (myxomycetes). Physarales is of particular interest since the two best-studied myxomycete species, Physarum polycephalum and Didymium iridis, belong to this order and are currently subjected to whole genome and transcriptome analyses. Here we report molecular phylogeny based on ribosomal DNA (rDNA) sequences that ...

    • The population structure of human carriage and clinical isolates of ESBL-producing Escherichia coli and Klebsiella pneumoniae in Norway 

      Andreassen, Lotte (Master thesis; Mastergradsoppgave, 2017-05-15)
      The increasing emergence of antimicrobial resistant bacteria worldwide is recognised as a severe threat to public health on a global scale. Without effective antimicrobial agents to treat bacterial infections, modern medicine will be set back several decades and deaths caused by bacterial infections will increase. The most widely used class of antimicrobials, is -lactams, and the increase in resistance ...

    • The population structure of vancomycin-resistant and -susceptible Enterococcus faecium in a low-prevalence antimicrobial resistance setting is highly influenced by circulating global hospital-associated clones 

      al Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen; Kacelnik, Oliver; Haldorsen, Bjørg C; Nygaard, Randi Monsen; Hegstad, Joachim; Sundsfjord, Arnfinn Ståle; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)
      Between 2010 and 2015 the incidence of vancomycin-resistant Enterococcus faecium (VREfm) in Norway increased dramatically. Hence, we selected (1) a random subset of vancomycin-resistant enterococci (VRE) from the Norwegian Surveillance System for Communicable Diseases (2010–15; n=239) and (2) Norwegian vancomycin-susceptible E. faecium (VSEfm) bacteraemia isolates from the national surveillance ...

    • A population-based study on health and living conditions in areas with mixed Sami and Norwegian settlements - The SAMINOR 2 questionnaire study 

      Brustad, Magritt; Hansen, Ketil Lenert; Broderstad, Ann Ragnhild; Hansen, Solrunn; Melhus, Marita (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)