Blar i tittel Institutt for medisinsk biologi

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    • E.S. Dietrichs og medarbeidere svarer 

      Dietrichs, Erik Sveberg; Solhaug, Vigdis; Haslemo, Tore; Kringen, Marianne K.; Molden, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-21)

    • Early pregnancy body mass index and spontaneous preterm birth in Northwest Russia: a registry-based study 

      Sharashova, Ekaterina; Anda, Erik Eik; Grjibovski, Andrej (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-04)

    • Early sexual behaviour and Chlamydia trachomatis infection - a population based cross-sectional study on gender differences among adolescents in Norway. 

      Gravningen, Kirsten Midttun; Furberg, Anne-Sofie; Simonsen, Gunnar Skov; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Early sexual behaviour has been shown to differ significantly between genders, but few studies have addressed this topic to explain the commonly observed differences in chlamydia rates between adolescent girls and boys. Our study aimed to determine chlamydia prevalence in adolescents aged 15–20 years in a high-incidence area in Norway, and to identify gender-specific early sexual behaviours associated ...

    • Eating and speech problems in oral and pharyngeal cancer survivors – Associations with treatment-related side-effects and time since diagnosis 

      Andreassen, Renate; Hadler-Oslen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-18)
      Aims: The aim of this cross-sectional study was to find factors associated with problems with the ability to eat and speak in oral and pharyngeal cancer (OPC) survivors and to evaluate if the panorama of oral problems varied with time since diagnosis.<p> <p>Methods and Results: A questionnaire assessing cancer diagnosis and treatment, oral health-related quality of life, and presence of ...

    • The effect of cell death in the initiation of lupus nephritis 

      Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01)

    • The effect of different feeding regimes on enzyme activities of gut microbiota in Atlantic cod (Gadus morhua L.) 

      Askarian, Fatemeh; Sperstad, Sigmund; Merrifield, Daniel L; Arun Kumar, Ray; Ringø, Einar (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The aims of this study were: (1) evaluate enzyme-producing bacteria isolated from the GI tract of Atlantic cod, (2) identify the most promising enzyme-producing bacteria by 16S rRNA gene sequencing and (3) to assess whether these bacteria have the ability to inhibit in vitro growth of four well known pathogenic bacteria; Aeromonas salmonicida subsp. salmonicida, V. (L.) anguillarum, Moritella viscosa ...

    • The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma 

      Almahmoudi, Rabeia; Salem, Abdelhakim; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Salo, Tuula; Al-Samadi, Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-20)
      Oral tongue squamous cell carcinoma (OTSCC) is one of the most common cancers worldwide and is characterized by early metastasis and poor prognosis. Recently, we reported that extracellular interleukin-17F (IL-17F) correlates with better disease-specific survival in OTSCC patients and has promising anticancer effects in vitro. Vasculogenic mimicry (VM) is the formation of an alternative vasculogenic ...

    • “EFFECT OF IRRADIATION ON THE IMMUNOREGULATORY FUNCTIONS EXERTED BY TUMOUR FIBROBLASTS ON MACROPHAGES” 

      Akhtar, Muhammad Asad (Master thesis; Mastergradsoppgave, 2018-11-19)
      Summary Background/aim of the study: Carcinoma-associated fibroblasts (CAFs) represents a heterogeneous population of cells and are considered one of the dominant stromal component of solid tumours, performing a crucial role in tumour proliferation and metastasis. The main objective of this study was to investigate the immunoregulatory features of CAFs isolated from non-small cell lung carcinomas ...

    • The effect of oral uptake of nicotine on skin blood perfusion of the face and hands in snus users as determined by thermography. 

      Høiland, Ina Isabella (Master thesis; Mastergradsoppgave, 2014-05-15)
      In recent years the number of people using cigarettes in Norway has significantly declined, with intake of nicotine being replaced by smokeless tobacco (ST) products such as snus placed in the oral cavity. While health risks from smoking cigarettes are well known little is known about health risks of using ST. The main aim of this thesis was to compare the effects of oral use of snus with nicotine ...

    • Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis 

      Rushfeldt, Christian; Agledahl, Uwe; Sveinbjørnsson, Baldur; Søreide, Kjetil; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)
      Background Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively. Methods This study includes a consecutive series of patients having surgery involving ...

    • The effect of resolvin D1 on bone regeneration in a rat calvarial defect model 

      Jiang, Xiaofeng; Liu, Jing; Li, Si; Qiu, Yingfei; Wang, Xiaoli; He, Xiaoli; Pedersen, Torbjørn Østvik; Mustafa, Kamal Babikeir Elnour; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)
      Resolvin D1 (RvD1) is a pro-resolving lipid mediator of inflammation, endogenously synthesized from omega-3 docosahexaenoic acid. The purpose of this study was to investigate the effect of RvD1 on bone regeneration using a rat calvarial defect model. Collagen 3D nanopore scaffold (COL) and Pluronic F127 hydrogel (F127) incorporated with RvD1 (RvD1-COL-F127 group) or COL and F127 (COL-F127 group) ...

    • The effect of Riociguat on cardiovascular function and efficiency in healthy, juvenile pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-12)
      <p><i>Introduction - </i>Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary hypertension. Its effect on cardiometabolic efficiency is unknown. A potential cardiac energy sparing effect of this drug could imply a positive prognostic effect, particularly in patients with right heart failure from pulmonary hypertension. <p><i>Method - </i>We infused Riociguat ...

    • The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers 

      Andriukaitiene, Laura; Song, Xiaobo; Yang, Nannan; Lippo V. J., Lassila; K. Vallittu, Pekka; Kerosuo, Eero (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      <p><i>Background</i>: The aim of the study was to assess bacterial sealability and bonding ability of methacrylate-based Resilon (RS, SybronEndo), Endo Rez (ER, Ultradent Products Inc), and epoxy-based AH Plus (AH, Dentsply/DeTrey), MTA Fill Apex (MTAF, Angelus Soluções Odontológicas) root canal sealers, and the effect of the smear layer removal on the sealability.</p> <p><i>Methods</i>: One ...

    • The effect of stimulation therapy and donepezil on cognitive function in Alzheimer's disease. A community based RCT with a two-by-two factorial design 

      Andersen, Fred; Viitanen, Matti; Halvorsen, Dag; Straume, Bjørn; Wilsgaard, Tom; Engstad, Torgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical exercise and cholinesterase inhibitors are both reported to postpone cognitive deterioration in separate studies. We aimed to study the effect of stimulation therapy and the additional effect ...

    • The effect of sub-lethal concentration of ciprofloxacin on the transfer of multidrug resistance plasmids, fitness costs on the host and the stability of the newly acquired plasmids 

      Mwansa, Besa James (Master thesis; Mastergradsoppgave, 2014-09-30)
      The increase in reported cases of antimicrobial resistance has raised a lot of concerns in the public health community. This has prompted efforts aimed at finding out factors that have been contributing to this situation. In Gram-negative bacteria plasmids have been singled out as the most important vehicles behind the spread of antimicrobial resistance. Some plasmids can harbour several resistance ...

    • Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways 

      Moens, Ugo; Macdonald, Andrew (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-12)
      Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the ...

    • The effect of traditional cupping on pain and mechanical thresholds in patients with chronic nonspecific neck pain : a randomised controlled pilot study 

      Lauche, Romy; Cramer, Holger; Hohmann, Claudia; Choi, Kyung-Eun; Rampp, Thomas; Saha, Felix Joyonto; Musial, Frauke; Langhorst, Jost; Dobos, Gustav J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Cupping has been used since antiquity in the treatment of pain conditions. In this pilot study, we investigated the effect of traditional cupping therapy on chronic nonspecific neck pain (CNP) and mechanical sensory thresholds. Fifty CNP patients were randomly assigned to treatment (TG, n = 25) or waiting list control group (WL, n = 25). TG received a single cupping treatment. Pain at rest (PR), ...

    • Effect of Unfractionated Heparin on TFPI Elimination 

      Øie, Cristina Ionica; Appa, Rupa Shree; Brodin, Ellen; Hilden, Ida; Smedsrød, Bård; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel, 2010)
      Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ...

    • Effect of viral early proteins, mutations and IL-17F on the transcriptional activity of the Merkel cell polyomavirus promoter in different cell lines 

      Abdulsalam, Ibrahim Afolabi (Master thesis; Mastergradsoppgave, 2016-05-23)
      Merkel cell polyomavirus (MCPyV) is common in the human population with a seropositivity of approximately 60%. The virus is chronically shed from healthy skin, but the genuine host cell remains unknown and a permissive cell culture system is lacking. The viral genome is in an episomal state in cells where MCPyV has been found. The virus is not harmful in healthy individuals, but it is involved in ...

    • Effectiveness of school-based preventive interventions on adolescent alcohol use: a meta-analysis of randomized controlled trials 

      Strøm, Henriette Kyrrestad; Adolfsen, Frode; Fossum, Sturla; Kaiser, Sabine; Martinussen, Monica (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-13)
      Background - Preventive interventions for adolescents are an important priority within school systems. Several interventions have been developed, but the effectiveness of such interventions varies considerably between studies. The purpose of this study was to assess the effectiveness of universal school-based prevention programs on alcohol use among adolescents by using meta-analytic techniques.<p ...