Now showing items 1795-1814 of 5604

    • Exploring the overlapping binding sites of ifenprodil and EVT‐101 in GluN2B‐containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling 

      Fjelldal, Marthe Fredheim; Freyd, Thibaud; Evenseth, Linn; Sylte, Ingebrigt; Ring, Avi; Paulsen, Ragnhild Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
      N‐methyl‐d‐aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit‐containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allosteric antagonists. We used primary cultures from chicken embryo forebrain (E10), expressing native GluN2B‐containing NMDA receptors as a novel model system. ...
    • Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder 

      Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-06)
      The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with evidence of subtle neurodevelopmental, structural and functional neuronal abnormalities. We aimed to elucidate the role of aberrant regulation of the Wnt system in these disorders ...
    • Exploring why and how encounters with the Norwegian health-care system can be considered culturally unsafe by North Sami-speaking patients and relatives: A qualitative study based on 11 interviews 

      Mehus, Grete; Bongo, Berit Andersdatter; Engnes, Janne Isaksen; Moffitt, Pertice (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)
      <p><i>Background - </i>Citizens of Norway have free and equal access to healthcare. Nurses are expected to be culturally sensitive and have cultural knowledge in encounters with patients. Culturally safe care is considered both a process and an outcome, evaluated by whether the patients feel safe, empowered and cared for, or not. All patients request equal access to quality care in Norway, also Sami ...
    • Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study 

      Fedirko, Veronika; Tran, Hao Quang; Gewirtz, Andrew T.; Stepien, Magdalena; Trichopoulou, Antonia; Aleksandrova, Krasimira; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Kühn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Bamia, Christina; Lagiou, Pagona; Grioni, Sara; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Naccarati, Alessio; Peeters, Petra H.; Bueno-De-Mesquita, Hendrik Bastiaan; Weiderpass, Elisabete; Castaño, José María Huerta; Barricarte, Aurelio; Sánchez, María-José; Dorronsoro, Miren; Quirós, José Ramón; Agudo, Antonio; Sjöberg, Klas; Ohlsson, Bodil; Hemmingsson, Oskar; Werner, Mårten; Bradbury, Kathryn E.; Khaw, Kay-Tee; Wareham, Nick; Tsilidis, Konstantinos K.; Aune, Dagfinn; Scalbert, Augustin; Romieu, Isabelle; Riboli, Elio; Jenab, Mazda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-04)
      Background:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide ...
    • Exposure to community violence, psychopathology, and personality traits in Russian youth. 

      Koposov, Roman A; Ruchkin, Vladislav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Previous research with the US inner-city youth demonstrated the hazardous effects of community violence exposure. It remains unclear, however, whether these findings are generalizable to other cultures and populations. Furthermore, the role of factors influencing the processing of traumatic events such as personality has not been investigated. Two groups of Russian adolescents (community youth (N ...
    • Expression and activity of NADPH oxidases (NOX) and the ROS-mediated effects on γ-Glutamyltransferase (GGT) expression in cancer cells 

      Ravuri, Chandra Sekhar (Doctoral thesis; Doktorgradsavhandling, 2010-12-10)
      Cancer cells with the ability to metastasize have also an ability to adapt and survive in new surroundings. This is connected to their ability to alter the balance between and the level of oxidants and antioxidants within the cell. To understand how cancer cells do this, a panel of cancer cells were examined with respect to genes that can affect the oxidant production. These cells had been isolated ...
    • Expression and function of the miR-143/145 cluster in vitro and in vivo in human breast cancer 

      Johannessen, Charles; Moi, Line; Kiselev, Yury; Pedersen, Mona Irene; Dalen, Stig Manfred; Braaten, Tonje; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-26)
      MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional regulators of gene expression and are dysregulated in cancer. Studies of miRNAs to explore their potential as diagnostic and prognostic markers are of great scientific interest. Here, we investigate the functional properties and expression of the miR-143/145 cluster in breast cancer (BC) in vitro and in vivo. The ER ...
    • Expression and functional properties of selected miRNAs in human cancer tissue and cancer cell lines 

      Johannessen, Charles Walquist (Doctoral thesis; Doktorgradsavhandling, 2019-03-01)
      MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) involved in the regulation of gene expression, and they are often seen dysregulated in cancer. For this reason, it is of great scientific interest to study these ncRNAs to better understand their distribution in human tissues and their mode of function. Based on a comprehensive miRNA microarray from 108 breast cancers in the Norwegian Woman and ...
    • Expression of adenylyl cyclase subtypes in endocrine pancreatic cell lines 

      Krum-Hansen, Sanda (Master thesis; Mastergradsoppgave, 2003-09)
    • Expression of G-Protein βγ Subunits in Endocrine Pancreatic cell Lines 

      Baug, Therese (Master thesis; Mastergradsoppgave, 2004-09)
    • The expression of miR-21 in prostate cancer measured by in situ hybridization and its relevance as a diagnostic biomarker 

      Melbø-Jørgensen, Christian Nordahl (Master thesis; Mastergradsoppgave, 2012-12-15)
      Background: Micro RNAs (miRNA) are a novel class of molecular regulators that have gained considerable attention in cancer research. Multiple studies in recent time have reported altered miRNA regulation in most cancers by deregulating of oncogenes and tumour suppressor genes. Additionally, certain tumours are represented by specific miRNA expression files. Prostate cancer is a markedly heterogeneous ...
    • Expression of phosphatase of regenerating liver (PRL)-3, is independently associated with biochemical failure, clinical failure and death in prostate cancer 

      Andersen, Sigve; Richardsen, Elin; Rakaee, Mehrdad; Bertilsson, Helena; Bremnes, Roy; Børset, Magne; Busund, Lill-Tove; Slørdahl, Tobias (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-30)
      Background: Prostate cancer (PC) stratification needs new prognostic tools to reduce overtreatment. Phosphatase of regenerating liver (PRL-3) is a phosphatase found at high levels in several cancer types, where its expression is associated with survival. A recent PC cell line study has shown it to be involved in PC growth and migration. <br>Methods: We used a monoclonal antibody to evaluate ...
    • Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Lund-Iversen, Marius; Berge, Gisle; Brustugun, Odd Terje; Solberg, Steinar; Mælandsmo, Gunhild; Pedersen, Kjetil Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. Four NSCLC cell lines were treated ...
    • Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae 

      Søraas, Arne Vasli Lund; Olsen, Ingar; Sundsfjord, Arnfinn; Handal, Trude; Bjørang, Ola; Jenum, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Extent of Preoperative False Lumen Thrombosis Does Not Influence Long-Term Survival in Patients With Acute Type A Aortic Dissection 

      Larsen, Magnus; Bartnes, Kristian; Tsai, TT; Eagle, KA; Evangelista, Arturo; Nienaber, CA; Suzuki, Toru; Fattori, Rossella; Forehlich, James B; Hutchinson, Stuart J.; Sundt, Thoralf M.; Januzzi, James L.; Isselbacher, Eric M.; Montgomery, Daniel G.; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background-—Partial thrombosis of the false lumen has been related to aortic growth, reoperations, and death in the chronic phase of type B and repaired type A aortic dissections. The impact of preoperative false lumen thrombosis has not been studied previously. We used data from a contemporary, multinational database on aortic dissections to evaluate whether different degrees of preoperative ...
    • Extent, Awareness and Perception of Dissemination Bias in Qualitative Research: An Explorative Survey 

      Toews, Ingrid; Glenton, Claire; Lewin, Simon; Berg, Rigmor C.; Noyes, Jane; Booth, Andrew; Marusic, Ana; Malicki, Mario; Munthe-Kaas, Heather M.; Meerpohl, Joerg J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-03)
      <b>Background</b> <br> Qualitative research findings are increasingly used to inform decision-making. Research has indicated that not all quantitative research on the effects of interventions is disseminated or published. The extent to which qualitative researchers also systematically underreport or fail to publish certain types of research findings, and the impact this may have, has received ...
    • Extent, regional variation and impact of gynecologist payment models in routine pelvic examinations: A nationwide cross-sectional study 

      Rosenlund, Ingvild Mathiesen; Leivseth, Linda; Nilsen, Ingard; Førde, Olav Helge; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-21)
      <p><i>Background - </i> Based on moderate quality evidence, routine pelvic examination is strongly recommended against in asymptomatic women. The aims of this study was to quantify the extent of routine pelvic examinations within specialized health care in Norway, to assess if the use of these services differs across hospital referral regions and to assess if the use of colposcopy and ultrasound ...
    • External validation of a prognostic score predicting overall survival for patients with brain metastases based on extracranial factors 

      Lewitzki, Victor; Klement, Rainer J; Hess, Sebastian; Kosmala, Rebekka; Nieder, Carsten; Flentje, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-27)
      <i>Purpose</i>: The aim of our study was an external validation of the extracranial prognostic score predicting survival of patients with brain metastases receiving cranial irradiation on data from a single institution.<p> <p><i>Materials and methods</i>: A retrospective analysis of 524 patients with brain metastases treated with cranial radiotherapy in a single tertiary center was performed. ...
    • External validation of prediction models for pneumonia in primary care patients with lower respiratory tract infection: An individual patient data meta-analysis 

      Schierenberg, Alwin; Minnaard, Margaretha C.; Hopstaken, Rogier M.; Van De Pol, Alma C.; Broekhuizen, Berna D.L.; De Wit, Niek J.; Reitsma, Johannes B.; Van Vugt, Saskia F.; Graffelman, Aleida W.; Melbye, Hasse; Rainer, Timothy H.; Steurer, Johann; Holm, Anette; Gonzales, Ralph; Dinant, Geert-Jan; De Groot, Joris A.H.; Verheij, Theo J.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-26)
      Background:<br> Pneumonia remains difficult to diagnose in primary care. Prediction models based on signs and symptoms (S&S) serve to minimize the diagnostic uncertainty. External validation of these models is essential before implementation into routine practice. In this study all published S&S models for prediction of pneumonia in primary care were externally validated in the individual patient ...