The overall aim of this doctoral thesis was to increase the understanding and knowledge of the prevalence and management of deep carious lesions. The prevalence of dental caries in Norway was among the highest in the world in the middle of 20th century. Though it has significantly declined, there are indications that the prevalence of caries in Northern Norway is higher than in the rest of the ...

Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images (WSIs) allows extraction of complex quantitative data that can be used to uncover different inflammatory patterns. We aimed to explore the distribution of CD3 and γδ T cells in colon ...

Growing evidence implicates impairment of autophagy as a candidate pathogenic mechanism in the spectrum of neurodegenerative disorders which includes amyotrophic lateral sclerosis and frontotemporal lobar degeneration (ALS-FTLD). SQSTM1, which encodes the autophagy receptor SQSTM1/p62, is genetically associated with ALS-FTLD, although to date autophagy-relevant functional defects in disease-ass ...

Recently Dittmer et al. (JED 6:1–9, 2018). suggested a transdiagnostic definition and a clinical assessment for compulsive exercise in adolescents and adults with eating disorders. In this letter to the editor, we extend the transdiagnostic bridge to the DSM-5-criteria for obsessive-compulsive disorders and hence raise the issue of exercise obsession without compulsive exercise actions. We argue ...

The topical administration of exogenous human epidermal growth factor (hEGF) is a promising approach for improved chronic wound therapy. To develop therapeutically superior hEGF formulation, we prepared hEGF-containing neutral (NDLs), cationic (CDLs) and anionic (ADLs) deformable liposomes (DLs), respectively, since it is expected that the liposomal surface charge can affect both the liposomal ...

Mattilsynet har gitt VKM i oppgave å foreta en risikovurdering når det gjelder ”dekontaminering av pattedyrslakt ved bruk av varmt vann eller damp”. Da det er en bestemtdekontamineringsteknologi Mattilsynet ønsker utredet, velger faggruppen å bruke den mer presise betegnelsen ”overflatepasteurisering av slakt” som er i tråd med uttrykk og definisjoner som forskere innenfor dette området har benyttet ...

Obesity is associated with the metabolic syndrome. The aims were, first, to study the postprandial triglyceride clearance in young, healthy obese subjects and, second, to investigate if fasting triglycerides can predict delayed postprandial triglyceride clearance. Eighteen apparently healthy, obese subjects with no clinical signs of metabolic disturbances participated. Controls were age‐ and ...

Delayed sleep phase syndrome er en søvnforstyrrelse som oppstår blant barn og unge voksne, som forårsaker vanskeligheter med å fungere normalt på dagtid når søvn-våken rytmen er forskjøvet. Diagnosen er vanlig, men det er allikevel ingen standardiserte rettningslinjer for behandling. Forskning de siste årene har funnet ut at hormonet melatonin påvirker søvn og endring av søvn-våken syklusen hos ...

Deliberation is commonly assumed to be a central characteristic of humans’ higher cognitive functions, and the responses following deliberation are attributed to mechanisms that are qualitatively different from lower-level associative or affectively driven responses. In contrast to this perspective, the current article’s aim is to draw attention to potential issues with making inferences about ...

Background: ST-segment changes to the fetal electrocardiogram (ECG) may indicate fetal acidosis. No large-scale characterization of ECG morphology immediately after birth has been performed, but ECG is used for heart rate (HR) assessment. We aimed to investigate ECG morphology immediately after birth in asphyxiated infants, using one-lead dry-electrode ECG developed for HR measurement. Methods: ...