Wnt signaling plays a pivotal role in maintaining bone mass. Secreted pathway modulators such as sclerostin (SOST) and Dickkopfs (DKKs) may influence bone mass inhibiting the canonical Wnt pathway. We evaluated whether bone protein content of secreted Wnt antagonists is related to age, bone mass, and strength in postmenopausal osteoporosis. We measured cortical and trabecular bone contents of SOST ...

Background:<br>Bone mineral density (BMD) is determined by bone remodeling processes regulated by endocrine, autocrine and genetic mechanisms. Thus, some studies have reported that BMD is associated with single nucleotide polymorphisms (SNPs) associated with vitamin D receptor (VDR), serum 25(OH)D levels and estrogen receptor 1 (ESR1), but without consensus. Therefore, we aimed to map and compare ...

Atherosclerosis is a major cause of morbidity and mortality in western world. Bone morphogenetic proteins are secreted regulatory proteins that regulate various processes throughout human body. Recent studies indicate their presence in atherosclerotic plaques and emerging role in plaque development. Since monocytes are the key effector cells in atherosclerosis, the aim of this thesis was to investigate ...

Low bone mass is prevalent in ambulatory multiple sclerosis (MS) patients even shortly after clinical onset. The mechanism is not known, but could involve shared etiological risk factors between MS and low bone mass such as hypovitaminosis D operating before disease onset, or increased bone loss after disease onset. The aim of this study was to explore the mechanism of the low bone mass in early-stage ...

Formålet med studiet var å undersøke sammenhengen mellom omsorgssvikt, tilknytningsstil og borderline personlighetsforstyrrelse. Det ble tatt utgangspunkt i eksisterende forskningslitteratur, og PRISMA´S retningslinjer for strukturert litteratursøk ble fulgt. På grunn av en mengde tidligere studier på dette feltet ble artikkelsøket avgrenset til å kun omhandle nyere litteratur fra januar 2013 til ...

This is the first study to determine the density of questing Ixodes ricinus in northern Norway. It was performed at two sites in Brønnøy, which has been known for its tick permissive habitats for decades and is one of the northernmost habitats with an abundant I. ricinus population in the world. From April to November 2011, all stages of host-seeking I. ricinus were collected from the two sites. ...

Bakgrunn: I 1991 startet HVPU-reformen som førte til nye botilbud for personer med psykisk utviklingshemming der målet var inkludering i samfunnet og en mest mulig selvstendig bosituasjon. I ettertid har det kommet flere rapporter som tyder på at utviklingen av bosituasjon har gått i retning av at flertallet bor samlokalisert, og mange i store bofellesskap. Material og metode: Masteroppgaven er ...

35 students have been participating in the program of educating Botswana medical students in Norway from 1995 until resent date. The purpose of this study has been to clarify the goal of the program and to find to what degree the program has been a success focusing on numbers of students having graduated, how many having returned home working as doctors, and the student’s experiences during their ...

Background - Health services worldwide have provided incentives for establishing teams to accommodate complex health care tasks, enhance patient outcomes and organizational efficiency, and compensate for shortages of health care professionals. Parallel to and partly due to the increased focus on teamwork, task shifting has become a health policy. Task shifting involves new tasks and responsibilities, ...

Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). Macrophages are particularly abundant in the porcine lung circulation. Upon bradykinin binding macrophages release cytokines and endothelial ...