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    • Cartilage Repair and Joint Preservation Medical and Surgical Treatment Options 

      Madry, Henning; Grün, Ulrich Wolfgang; Knutsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Articular cartilage defects are most often caused by trauma and osteoarthritis and less commonly by metabolic disorders of the subchondral bone, such as osteonecrosis and osteochondritis dissecans. Such defects do not heal spontaneously in adults and can lead to secondary osteoarthritis. Medications are indicated for symptomatic relief. Slow-acting drugs in osteo - arthritis (SADOA), such as ...

    • The case of case reports: A decade of publications by staff at a major university hospital 

      Nissen, Trygve; Bergvik, Svein; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      <p><i>Rationale:</i> The place of case reports in the medical literature has been much debated in recent years. This study was undertaken to gain knowledge about the publication practice of case reports and case series from a major university hospital. <p><i>Method:</i> We decided to conduct a retrospective, bibliographic, descriptive study of published case reports and case series from a university ...

    • The catalytic reaction mechanism of drosophilid alcohol dehydrogenases 

      Wushur, Imin; Sylte, Ingebrigt; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-12-24)
      The present review describes the current knowledge about the reaction mechanism of drosophilid alcohol dehydrogenases (DADH), a member of the short chain dehydrogenase/reductase (SDR) superfamily. Included is the binding order of the substrates to the enzyme, rate limiting steps, stereochemistry of the reaction, active site topology, role of important amino acids and water molecules in the reaction ...

    • The Category-Focus Implicit Association Test 

      Siebler, Frank; González, Roberto; Ordóñez, Gabriela; Bohner, Gerd; Haye, Andrés; Sirlopú, David; Millar, Andres; De Tezanos-Pinto, Pablo; Torres, David (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Caught up in Care: Crafting Moral Subjects of Chronic Fatigue 

      Risør, Mette Bech; Lillevoll, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)
      Patients with chronic fatigue receive advice to improve symptom management and well-being. This advice is based on ideas of self-management and is conveyed during clinical assessment as “activity regulation.” Based on ethnographic fieldwork in a hospital clinic in Norway, we show how these patients attempt to demonstrate their competences and everyday concerns, and how the ideology of self-management ...

    • Causal modelling of variation in clinical practice and long-term outcomes of ADHD using Norwegian registry data: The ADHD controversy project 

      Mykletun, Arnstein; Widding-Havneraas, Tarjei; Chaulagain, Ashmita; Lyhmann, Ingvild; Bjelland, Ingvar; Halmøy, Anne; Elwert, Felix; Butterworth, Peter; Markussen, Simen; Zachrisson, Henrik Daae; Rypdal, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      <p><i>Introduction:</i> Attention-deficit/hyperactivity disorder (ADHD) is among the most common mental disorders in children and adolescents, and it is a strong risk factor for several adverse psychosocial outcomes over the lifespan. There are large between-country and within-country variations in diagnosis and medication rates. Due to ethical and practical considerations, a few studies have examined ...

    • Cause for Concern? The value of practical knowledge in professional education 

      Mæhre, Kjersti Sunde; Halås, Catrine Torbjørnsen; Hvitsten, Bente Isabell Borthne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
      The aim of this paper is to explore how practical knowledge can enhance higher education and Bildung for the human service professions. The paper sheds light on how governance reforms such as New Public Management have influenced higher education, where we argue that scientific rationality has weakened the professional’s autonomy and responsibility. The paper is based on the three authors’ experiences ...

    • Cause for concern? The value of practical knowledge in professional education 

      Mæhre, Kjersti Sunde; Hvidsten, Bente Isabell Borthne; Halås, Catrine Torbjørnsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
      The aim of this paper is to explore how practical knowledge can enhance higher education and Bildung for the human service professions. The paper sheds light on how governance reforms such as New Public Management have influenced higher education, where we argue that scientific rationality has weakened the professional’s autonomy and responsibility. The paper is based on the three authors’ experiences ...

    • Cause-specific excess mortality after hip fracture: the Norwegian Epidemiologic Osteoporosis Studies (NOREPOS) 

      Holvik, Kristin; Ellingsen, Christian Lycke; Solbakken, Siri Marie; Finnes, Trine Elisabeth; Talsnes, Ove; Grimnes, Guri; Tell, Grethe Seppola; Søgaard, Anne-Johanne; Meyer, Haakon Eduard (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Background Information on cause of death may help appraise the degree to which the high excess mortality after hip fracture refects pre-existing comorbidities or the injury itself. We aimed to describe causes of death and causespecifc excess mortality through the frst year after hip fracture.<p> <p>Methods For studying the distribution of causes of death by time after hip fracture, we calculated ...

    • Causes and Consequences of Gender Roles 

      Olsson, Maria (Doctoral thesis; Doktorgradsavhandling, 2021-05-03)
      This dissertation addresses the pervasive issue of women’s underrepresentation in agentic work and the equally important (but underexamined) issue of men’s underrepresentation in communal unpaid work. First, I review research and identify what conditions need to be met in order for counterstereotypical role models to break down some of the barriers to women’s entry into agentic work (Chapter 2). One ...

    • Causes and consequences of stress. Interplay between cognitive social and biological aspects 

      Nolen, Kristi Shannon (Master thesis; Mastergradsoppgave, 2015-11-03)
      The purpose of this article is to explore the roles of cognitive, social and biological reasons for stress and to relate practical interventions to them. Understanding stress and how it can play out is pivotal in managing it. The physiological stress response works much in the same manner in individuals everywhere; first observing something that is potentially perceived as a threat to the self, and ...

    • Causes of Infant Mortality in Botswana 

      Bogatsu, Yaone (Master thesis; Mastergradsoppgave, 2012-06-01)
      Introduction: Infant mortality rate of Botswana has not reduced substantial in the last two decades (1990-2009); the HIV/AIDS epidemic has not helped the situation either. The aim of this project was to determine the major causes of infant death in Botswana and what the government is doing about it. Method: The statistical data used was from the Mortality and Morbidity report of 2006 from ...

    • CCL17/TARC and CCR4 expression in Merkel cell carcinoma 

      Rasheed, Kashif; Abdulsalam, Ibrahim Afolabi; Fismen, Silje; Grimstad, Øystein; Sveinbjørnsson, Baldur; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-31)
      Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. In more than 80% of the cases, Merkel cell polyomavirus (MCPyV) is a causal factor. The oncogenic potential of MCPyV is mediated through its viral oncoproteins, large T antigen (LT) and small t antigen (sT). To investigate the role of cytokines in MCC, a PCR array analysis for genes encoding inflammatory cytokines ...

    • CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray 

      Lau, Corinna; Nygård, Ståle; Fure, Hilde; Olstad, Ole Kristoffer; Holden, Marit; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-23)
      Systemic inflammation like in sepsis is still lacking specific diagnostic markers and effective therapeutics. The first line of defense against intruding pathogens and endogenous damage signals is pattern recognition by e.g., complement and Toll-like receptors (TLR). Combined inhibition of a key complement component (C3 and C5) and TLR-co-receptor CD14 has been shown to attenuate certain systemic ...

    • CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in Granulomatosis with polyangiitis patients 

      Besada, Emilio; Nossent, Johannes C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-20)
      <b>Introduction</b> <br> Rituximab (RTX) is a B cell-depleting agent approved for the treatment of granulomatosis with polyangiitis (GPA). RTX reduces antibody producing precursor plasma cells and inhibits B and T cells interaction. Infections related to T cell immunodeficiency are not infrequent during RTX treatment. Our study investigated CD4 cell count and CD4/CD8 ratio in GPA patients during the ...

    • CD4/CD8 co-expression shows independent prognostic impact in resected non-small cell lung cancer patients treated with adjuvant radiotherapy 

      Hald, Sigurd; Bremnes, Roy M.; Al-Shibli, Khalid; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)

    • CD45RO+ Memory T Lymphocytes – a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer 

      Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rakaeekhanehkenari, Mehrdad; Johansen Maurseth, Ramona; Al-Saad, Samer; Hald, Sigurd; Al-Shibli, Khalid; Andersen, Sigve; Richardsen, Elin; Busund, Lill-Tove; Bremnes, Roy M.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Tumor-infiltrating lymphocytes (TILs) are vital in limiting cancer progression and may supplement the TNM classification. CD45RO+ memory TILs show major prognostic impact in various malignancies but have not been extensively explored in non–small cell lung cancer (NSCLC). In this study, we aimed to evaluate their potential in a NSCLC TNM-Immunoscore. Tissue microarrays were constructed from tumor ...

    • Celecoxib, NSAIDs og cancer. 

      Sundnes, Morten Juul (Master thesis; Mastergradsoppgave, 2005)

    • Cellular and molecular mediators of intestinal fibrosis 

      Lawrance, Ian; Rogler, Gerhard; Bamias, Giorgos; Breynaert, Chrstine; Florholmen, Jon; Pellino, Gianluca; Reif, Shimon; Speca, Silvia; Latella, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-02)
      Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, ...

    • Center-TBI og traumatiske hjerneskader. Prinsipper for behandling av traumatiske hjerneskader og diagnostikk av respirasjonssvikt som en del av CENTER-TBI. 

      Kramvik, Maria Johansdatter (Master thesis; Mastergradsoppgave, 2018-06-04)
      Amerikanske Brain Trauma Foundation (BTF) har utarbeidet retningslinjer for behandling av traumatiske hjerneskader (THS). Den europeiske multisenter studien Center- TBI har som mål å kartlegge patofysiologien bak og behandlingen av pasienter med denne skadetypen. Det er usikkert hvorvidt studien har inkludert sentrale variabler fra BTF retningslinjer i sitt eCRF. Når en skal sammenligne forløp og ...