<p><i>Background:</i> Evidence suggests that the link between obesity and chronic lifestyle disease is chronic, low-grade inflammation. Leptin and adiponectin play principal roles in inducing inflammation and promoting insulin resistance, resulting in metabolic syndrome. Our study aimed to find clinically feasible biologic markers to identify metabolically dysregulated obese individuals and to study ...

Irregular attendance in breast cancer screening has been associated with higher breast cancer mortality compared to regular attendance. Early performance measures of a screening program following regular versus irregular screening attendance have been less studied. We aimed to investigate early performance measures following regular versus irregular screening attendance. Methods We used information ...

Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ...

Purpose: To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography (DM) (To-Be 1) and a follow-up cohort study using DBT (To-Be 2). <p><p>Methods: Retrospective results of 125,020 screening examinations from four consecutive screening rounds ...

Early sexual behaviour has been shown to differ significantly between genders, but few studies have addressed this topic to explain the commonly observed differences in chlamydia rates between adolescent girls and boys. Our study aimed to determine chlamydia prevalence in adolescents aged 15–20 years in a high-incidence area in Norway, and to identify gender-specific early sexual behaviours associated ...

<p><b> Objective</b> To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. <p><b> Setting</b> All neonatal intensive care units (NICUs) in Norway during 2012–2018. <p><b> Methods</b> Defined population-based data were prospectively entered into a national registry. We ...

<i>Background</i>: The epidemiology of early-onset sepsis (EOS) may change over time. Longitudinal surveillance of causative pathogens, antibiotic susceptibility patterns and antibiotic therapy is important for optimal therapy strategies.<br><br> <i>Objectives</i>: To describe the incidence of culture-confirmed EOS, causative pathogens, antibiotic susceptibility patterns and antibiotic therapy ...

Innledning: I denne oppgaven tok vi utgangspunkt i ebola virus disease (EVD)-epidemien som rammet Vest-Afrika i 2014-2015. En epidemi som rammet flere land i løpet av få måneder, ble raskt det største EVD-utbruddet i historien og førte til stor bekymring, ikke bare blant befolkningen i Vest-Afrika, men også over store deler av verden. Jeg lurte derfor på om det fantes en sammenheng mellom epidemiologiske ...

Decades of research have greatly improved our understanding of intrinsic human brain organization in terms of functional networks and the transmodal hubs within the cortex at which they converge. However, substrates of multinetwork integration in the human subcortex are relatively uncharted. Here, we leveraged recent advances in subcortical atlasing and ultra-high field (7 T) imaging optimized for ...