Background - This study aimed to develop a novel positron emission tomography (PET) tracer, [⁶⁸Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it suitable for ⁶⁸Ga radiolabeling.<p> <p>Methods - A bifunctional chelator was prepared by conjugating the amine group of TIQ15 with ...

Purpose: This study evaluated the long-term safety of roflumilast in patients with chronic obstructive pulmonary disease or chronic bronchitis using electronic healthcare databases from Germany, Norway, Sweden, and the United States (US). <p> <p>Patients and Methods: The study population consisted of patients aged ≥ 40 years who had been exposed to roflumilast and a matched cohort unexposed to ...

En mann i 70-årene med raskt progredierende metastatisk prostatakreft hadde mottatt kastrasjonsbehandling i fire år og utviklet kastrasjonsresistent sykdom. Videre hadde han effekt og god toleranse av abiraterontabletter i 3,5 år (daglig dose 1000 mg samt prednisolon 10 mg for å dempe bivirkninger). Abirateron ble seponert da det så tilkom sykdomsprogrediering med stigende prostataspesifikt antigen ...

Objective: To describe the needs for subacute inpatient rehabilitation and community-based healthcare services, rehabilitation, and social support in patients with moderate-to-severe traumatic injury in the first 6 months post-injury. Further, to explore associations between sociodemographic and clinical characteristics and unmet needs.<p> <p>Design: Multicentre prospective cohort study. <p>Subjects: ...

Background The global discourse on future health care emphasises that learning to collaborate across professions is crucial to assure patient safety and meet the changing demands of health care. The research on interprofessional education (IPE) is diverse but with gaps in curricula design and how IPE is enacted in practice.<p> <p>Purpose and aims This research project will identify. 1) how IPE ...

Hypertension, which affects about one-third of adults worldwide, is a leading cause of heart disease, stroke, and kidney failure. Despite the known benefits of lowering blood pressure, control remains inadequate worldwide. Only half of those with hypertension are aware of their condition, and even fewer receive adequate treatment. Among those treated, many do not achieve target blood pressure levels. ...

The association between self-assessed cold threshold (CT) and thermal insulation of clothing (Icl) was analysed in 283 poultry workers in Thailand. The mean CT was 13.5 °C (range − 28–29) and the mean Icl was 1.23 clo (range 0.35–2.21). The adjusted CT remained unchanged at low Icls (0.35 through 1.25 clo) but was estimated to increase by 14.8 °C at high Icls (1.25 through 2.21 clo). Overall, CT was ...

Objectives - To assess the ability of baseline serum biomarkers to predict disease activity and remission status in juvenile idiopathic arthritis (JIA) at 18-year follow-up (FU) in a population-based setting.<p> <p>Methods - Clinical data and serum levels of inflammatory biomarkers were assessed in the longitudinal population-based Nordic JIA cohort study at baseline and at 18-year FU. A panel ...

The Arctic Monitoring Assessment Program (AMAP) is tasked with monitoring and assessing the status of environmental contaminants in the Arctic, documenting levels and trends, and producing science-based assessments. The objectives of this paper are to present the current levels of persistent organic pollutants (POPs) across the Arctic, and to identify trends and knowledge gaps as detailed in the ...

Ensuring adequate iodine nutrition during pregnancy is crucial for fetal brain development. Thus, the WHO recommend monitoring iodine nutrition in pregnant women. With changing dietary habits and declining iodine intake in coastal populations, iodine nutrition in pregnant Faroese women was a focus in newly established pregnancy cohorts. This study aimed to monitor the iodine status of pregnant women ...