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norskBlar i tittel Doktorgradsavhandlinger (Helsefak)
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The development and use of a new tool for estimating individual sun induced vitamin D in epidemiological surveys
(Doctoral thesis; Doktorgradsavhandling, 2010-11-19) -
The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model
(Doctoral thesis; Doktorgradsavhandling, 2021-04-23)Oral drug administration is the most convenient route to systemically deliver drugs because of its cost-effectiveness, ease of administration and high patient compliance. However, when a drug is orally administered it will be exposed to the different physiological processes and environments found along the gastrointestinal (GI) tract, which will determine its ability of being absorbed and reach the ... -
Development of a prognostic model for unfavorable outcome after lumbar microdiscectomy
(Doctoral thesis; Doktorgradsavhandling, 2021-05-11)The aim of this thesis was to develop a prognostic model for unfavorable outcome 12 months after surgical treatment of a lumbar disc herniation (lumbar microdiscectomy). While the surgical procedure is rather uniform, with little technical variation, the reported outcomes are quite heterogenous. This might be due to different expectations by patients, or due to suboptimal surgical indication as ... -
Development of biomimetic phospholipid vesicle-based permeation assays (PVPA) as screening tool in drug development
(Doctoral thesis; Doktorgradsavhandling, 2015-04-17)Although several routes of administration can be utilized to bring a drug to the desired site of action, oral administration is still the most important and prevalent route of administration, due to its cost efficiency, convenience and patient compliance. A prerequisite for successful oral therapy is the ability of a drug to cross the gastrointestinal barrier. Over the past two decades, the ... -
Development of osmotically active liposomes for nose-to-brain drug delivery
(Doctoral thesis; Doktorgradsavhandling, 2019-11-22)The brain as a drug target site remains a pharmaceutical challenge in spite of numerous efforts to enhance drug delivery to the brain. Nasal drug administration has gained interest among researchers, especially in the last decade, as it provides direct drug access into the brain. However, the nasal mucus and the surrounding environment often limit the use of nose as the administration site. Drug ... -
Diagnosis of cancer in general practice : a study of delay problems and warning signals of cancer, with implications for public cancer information and for cancerdiagnostic strategies in general practice
(Doctoral thesis; Doktorgradsavhandling, 1991-01-26)Early diagnosis of cancer is beneficial to most cancer patients. This doctoral thesis is based on studies in general practice in Tromsø, Norway, during the years 1978-1985. General practitioners have a very important role in the work excluding or leading up to a cancer diagnosis. The studies deal with diagnostic delay, the value of symptoms, and with strategies for GP s to improve their cancer ... -
Diagnosis of pneumonia in adults in general practice.
(Doctoral thesis; Doktorgradsavhandling, 1992) -
Diagnostic tests for lung and heart diseases in primary care - from quality assurance to epidemiology
(Doctoral thesis; Doktorgradsavhandling, 2018-11-02)The use of pulse oximetry and spirometry tests in general practice is increasing. Pulse oximetry is a non-invasive method for measuring oxygen saturation (SpO2). The pulse oximeter is a helpful tool in primary care because it is tolerable for the patient, easy to use and acceptable within the time constraints of a busy practice. Spirometry is used in both diagnosis and monitoring of respiratory ... -
Diet, dietary supplements and dietary change in cancer survivors and cancer-free persons : the Norwegian Women and Cancer study and the European Prospective Investigation into Cancer and Nutrition
(Doctoral thesis; Doktorgradsavhandling, 2009-09-11)This thesis focuses on diet and dietary change in women who have breast or colorectal cancer, compared to cancer-free women in the Norwegian Women and Cancer study (NOWAC; Kvinner og kreft). The use of dietary supplements in the European Prospective Investigation into Cancer and Nutrition (EPIC) is also described. Finally, the association between use of cod liver oil and other supplements and survival ... -
Diet, physical activity and venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2014-01-17)Summary There is substantial evidence for the influence of life-style factors on the incidence of arterial thromboembolic diseases such as myocardial infarction and stroke. However, limited knowledge exists on the relation between life-style factors and venous thromboembolism (VTE). VTE, a collective term for deep vein thrombosis and pulmonary embolism, is a common disease with serious short- and ... -
Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2020-11-27)Venøs tromboembolisme (VTE) er en fellesbetegnelse på dyp venetrombose (DVT) og lungeemboli (LE). VTE er en vanlig og alvorlig karsykdom hvor forekomsten har vært svakt økende de siste årene. Marine omega-3 fettsyrer (n-3 PUFAs) har flere gunstige effekter på hemostasemekanismen. Målet med denne doktorgradsavhandlingen var å undersøke sammenhengen mellom inntak av marine n-3 PUFAs i kosten og risikoen ... -
Differential processing strategies in face perception
(Doctoral thesis; Doktorgradsavhandling, 2010-09-24)Faces constitute a unique object class in that they include extensive information about many aspects of human interaction, and still imply expert processing of individual subordinate-level objects. It is necessary to understand such a basic skill before progress in applied research can take place. The present thesis describes several experimental studies that investigated different basic attributes ... -
Differentiated birth care for low-risk women Medical and economic perspectives
(Doctoral thesis; Doktorgradsavhandling, 2013-03-08) -
Discovery and detection of phase-II metabolites of exogenous steroids in anti-doping analysis
(Doctoral thesis; Doktorgradsavhandling, 2022-04-29)Anti-doping measures are an essential part of professional sports around the world. Anabolic androgenic steroids have been among the most widely used illicit substance classes since the early days of the fight against doping. The conventional method for analysing these substances is gas chromatography combined with mass spectrometry (GC-MS). This approach is sensitive and selective but also very ... -
Disease activity and outcome in juvenile idiopathic arthritis - a longitudinal cohort study in the Nordic countries
(Doctoral thesis; Doktorgradsavhandling, 2012-05-16)SUMMARY This thesis is based on the Nordic juvenile idiopathic arthritis (JIA) cohort study. In a multi-centre population-based setting a prospective followup of juvenile idiopathic arthritis (JIA) was performed. Pediatric rheumatology centers in Denmark, Finland, Norway and Sweden included children with newly diagnosed JIA during a 3.5 year period starting January 1st 1997. The study was focused ... -
A doctor close at hand : a qualitative analysis of GPs' work in cancer care
(Doctoral thesis; Doktorgradsavhandling, 2012-08-31)Summary of thesis The core of medicine, even specialized and high-tech medicine, is a meeting, a consultation, between a human being asking for advice and another human being, whose knowledge and experience is expected to be helpful. This thesis explores how the suspicion of cancer can arise in such a consultation, how general practitioners (GPs) can contribute to cancer care and how GPs might ... -
Drug resistance and the functional role of microRNAs in neuroblastoma
(Doctoral thesis; Doktorgradsavhandling, 2019-06-13)Neuroblastoma is the most common solid tumor in infants. Most of the children diagnosed above one year of age, shows metastatic disease and poor prognosis. Chemotherapy is one of the principle mode of treatment. However, resistance to drug represent a major clinical obstacle for the effective treatment of cancer. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression, ... -
Dynamic functional assessment of maternal hemodynamics in human pregnancy
(Doctoral thesis; Doktorgradsavhandling, 2016-09-09)Pregnancy causes significant changes in maternal circulation and cardiac function. In healthy pregnancy the blood volume, heart rate, stroke volume and cardiac output are known to increase and these physiological alterations are largely complete by mid-gestation. Investigation into cardiovascular response to dynamic changes in the loading condition of heart during pregnancy might contribute to better ... -
Dysfunctional eating behaviours and personality traits in severely obese patients undergoing bariatric surgery
(Doctoral thesis; Doktorgradsavhandling, 2015-05-21)The PSYMO study is a randomised controlled trial including 102 severely obese patients undergoing bariatric surgery. Firstly, we examined the relationships between dysfunctional eating behaviours (DE), personality, anxiety and depression. Secondly, we examined whether a pre-surgical cognitive behavioural therapy (CBT) intervention exceeds usual care in the improvements of dysfunctional eating ... -
Dyspepsia in the young adult patient: Management strategies in the era of declining Helicobacter pylori prevalence and increasing antimicrobial resistance
(Doctoral thesis; Doktorgradsavhandling, 2013-06-21)Helicobacter pylori (H. pylori) is the main cause of peptic ulcer disease (PUD), followed by regular consumption of non-steroidal anti-inflammatory drugs (NSAIDs). The occurrence of gastric cancer is very low below the age of 45-50 years and thus does not justify any kind of symptom-based endoscopic screening. H. pylori also plays a well-documented, but minor role in functional dyspepsia (FD). In ...
