Blar i tittel Doktorgradsavhandlinger (Helsefak)
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Prevalence, vascular complications, and level of health care treatment in individuals with type 2 and type 1 diabetes mellitus
(Doctoral thesis; Doktorgradsavhandling, 2022-10-04)The total prevalence of diabetes and vascular complications is increasing. Consequently, it is important to provide diabetes treatment according to the National clinical guideline for the management of diabetes and allocate individuals to the right level of health care in line with the National guideline for prioritization in specialist health care – Endocrinology and endocrine surgery. We used data ... -
Prevention of Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) by prophylactic monoclonal antibodies. In vitro and preclinical evaluation of HPA-1a-specific antibodies
(Doctoral thesis; Doktorgradsavhandling, 2023-10-19)The focus of this thesis is the condition fetal/neonatal alloimmune thrombocytopenia (FNAIT) where maternal alloantibodies toward paternally inherited human platelet antigens (HPAs) cause depletion of fetal platelets. Clinical outcomes are heterogenous and can be asymptomatic, mild or severe bleedings, where intracranial hemorrhage (ICH) is the feared outcome as it may lead to lifelong disabilities ... -
Prognosis in acute aortic dissection. Insights from the International Registry of Acute Aortic Dissection
(Doctoral thesis; Doktorgradsavhandling, 2018-06-20)<p><i>Background/aims:</i> Acute aortic dissection (AAD) is a rare life-threatening disease that does not easily lend itself to randomized controlled trials. Data regarding the effect of treatment advances in the recent decades is limited. Determinants of follow-up mortality are poorly understood. To include many patients and evaluate contemporary management of AAD, the International Registry ... -
The prognostic impact of immune-related markers in non-small cell lung cancer
(Doctoral thesis; Doktorgradsavhandling, 2017-06-15)Lung cancer is the leading cancer killer worldwide and non-small cell lung cancer (NSCLC) is the predominant subtype of lung cancer. The immune system plays an important role in cancer development. Immune-related markers expressed in the tumor microenvironment of resection specimens predict prognosis in many cancers, and may be potential targets for therapy. We aimed to characterize the expression ... -
Prognostic impact of molecular markers related to tumor proliferation and differentiation in non-smallcell lung cancer (NSCLC)
(Doctoral thesis; Doktorgradsavhandling, 2010-04-29)Lungekreft er krefttypen med den høyeste dødelighet av alle andre krefttyper. Hvert år får ca. 1,3 millioner mennesker av begge kjønn denne sykdommen på verdensbasis og mer enn 1,1 millioner mennesker dør av den. Det er en sterk sammenheng mellom røyking og lungekreft. Man kan få et bilde av en befolknings røykevaner ved å undersøke hyppigheten av lungekreft. For mer enn 10 år siden begynte man i ... -
Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009
(Doctoral thesis; Doktorgradsavhandling, 2020-10-08)Oral cavity cancer (OCC) is the most frequent of head and neck cancers, most being squamous cell carcinomas (SCC). Within the oral cavity, the oral tongue is the most common site of cancer. These cancers are very aggressive, with poor survival. The treatment decision is based upon classifications of tumor (T), lymph node (N), and metastasis (M), although tumors with the same classification may act ... -
Prognostic markers in oral squamous cell carcinoma
(Doctoral thesis; Doktorgradsavhandling, 2014-06-20)Avhandlingen er basert på 5 artikler. Vi har retrospektivt innhentet klinisk informasjon om 133 pasienter diagnostisert med cancer i munnhulen ved UNN i perioden 1986-2001, og laget Tissue Micro Arrays (TMA) av tumorvev fra de respektive pasientenes svulster. Den første artikkelen er en epidemiologisk beskrivelse av materialet. Artikkel 2 og 3 omfatter ulike potensielle prognostiske markører for ... -
The prognostic significance of the innate and adaptive immune systems in non-small cell lung carcinoma
(Doctoral thesis; Doktorgradsavhandling, 2010-05-27)Lungekreft er knyttet til røyking og har den høyeste dødelighet av alle andre krefttyper. Hvert år får ca. 1,3 millioner mennesker av begge kjønn denne sykdommen på verdensbasis og mer enn 1,1 millioner mennesker dør av den. En britisk analyse publisert i forskningsmagasinet Nature, bekreftet at det forskes lite på lungekreft i forhold til andre kreftformer. I analysen sto lungekreft bak 22 prosent ... -
Prognostic value of adaptive and innate immune system in soft tissue sarcomas
(Doctoral thesis; Doktorgradsavhandling, 2013-09-26)The purpose of this study was to clarify the prognostic significance of the adaptive and innate immune system in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has ... -
Progressive lupus nephritis : biological consequences of renal DNaseI gene silencing
(Doctoral thesis; Doktorgradsavhandling, 2013-10-11)Systemic lupus erythematous (SLE) is an autoimmune syndrome which occurs most often between the ages 10-50 years. Lupus nephritis is the most severe clinical manifestation of SLE. 30-60% of the SLE patients may develop lupus nephritis during lifetime. At a certain time point in the life of (NZBxNZW) F1 mice prone to develop lupus nephritis, the expression of renal DNaseI endonuclease is lost. This ... -
Prolonged Cardiopulmonary Resuscitation in Accidental Hypothermia: Physiological and pathophysiological effects of cardiopulmonary resuscitation (CPR) in hypothermia regarding hemodynamics, oxygen transport and regional blood flow
(Doctoral thesis; Doktorgradsavhandling, 2023-12-21)This thesis was aimed to examine the physiological and pathophysiological effects of 3 hours continuous cardiopulmonary resuscitation (CPR) at 27°C concerning hemodynamics, oxygen transport, and regional blood flow. We aimed to explore mechanisms responsible for the successful resuscitation of accidental hypothermia victims in hypothermic cardiac arrest (HCA) and evaluate their value during prolonged ... -
Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells
(Doctoral thesis; Doktorgradsavhandling, 2010-12-03)The work is part of a larger thematic research initiative, “Airway reactions to biological particles derived from seafood”, and was initiated in 2005 after a study conducted in the Norwegian fish industry revealed increased airway symptoms in fish industry workers. The thesis investigates the ability fish and king crab trypsins have to affect airway epithelial cells and the initiation of intracellular ... -
The proteome of ulcerative colitis - Functional analyses of the active disease and the remission state in comparison with healthy controls
(Doctoral thesis; Doktorgradsavhandling, 2019-06-18)This work characterizes the proteome of human colon mucosa in ulcerative colitis (UC). We developed an optimized sample preparation method of colon mucosa biopsies for bottom-up proteomics and applied it to characterize the proteomes of active UC, remission from UC, and healthy controls. Abundances of proteins related to the immune system and to protein processing in the endoplasmic reticulum ... -
Providing a short and effective transdiagnostic treatment intervention and a valid outcome measure for adolescent with anxiety and depression. A randomized controlled trial of the SMART intervention and validation of the CORE-OM in adolescents aged 14 to 17
(Doctoral thesis; Doktorgradsavhandling, 2022-12-15)Anxiety and depression are the most prevalent mental health problems among children and adolescents, and the consequences can be harmful if they are left untreated. Providing short and effective treatment for this group is paramount. When this effectiveness study of The Structured Material for Therapy (SMART) was conducted, it was the first Randomized Controlled Trial (RCT) of short-term transdiagnostic ... -
Providing an indicated preventive intervention for children with symptoms of anxiety and depression: A study of effectiveness, implementation factors, and program fidelity
(Doctoral thesis; Doktorgradsavhandling, 2019-09-12)<p><i>Background - </i>Anxiety and depression are the most prevalent disorders among children and adolescents, and the consequences could be life damaging if these problems are ignored. However, implementing psychosocial interventions in real-life settings to prevent these issues is challenging and complex procedure. The main goals of this thesis were to investigate the effectiveness of the EMOTION: ... -
Psoriasis, overweight and metabolic syndrome. The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2014-05-28)Recently it has been suggested that the chronic inflammatory disease psoriasis is more than skin deep, as it has been associated with several comorbid conditions, including diabetes and cardiovascular disease. Increasing prevalence of psoriasis has been observed, possibly due to changes in lifestyle. Within the population-based Tromsø study cohort, we found an increase in the self-reported prevalence ... -
Psychological factors in the recovery of coronary artery disease patients in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2009-06-05)The thesis comprises four studies of psychosocial factors associated with the recovery of patients following Coronary Artery Bypass Graft (CABG) surgery and Percutaneous Coronary Intervention (PCI) treatment in Northern Norway. Paper I describes an interview study of nine patients following CABG surgery. The patients reported extensive use of avoidant (e.g. neglecting symptoms, avoiding thoughts ... -
Psychosocial predictors of an interest in cosmetic surgery : based on a population study of young Norwegian women
(Doctoral thesis; Doktorgradsavhandling, 2012-03-30)This thesis aims to provide more knowledge about psychological and social aspects of cosmetic surgery, in particular what factors are associated with the increased interest in having such surgery oneself. The first paper is angled from a more public health perspective, with focus on what factors predicts whether someone considers having cosmetic surgery in general. In the second paper, the focus ... -
Psykiske belastninger ved svangerskap og fødsel - med fokus på fødselsangst, ønske om keisersnitt og tidligere seksuelle overgrep
(Doctoral thesis; Doktorgradsavhandling, 2013-09-06)Bakgrunn: Forløp og utfall av en fødsel har i liten grad vært satt i sammenheng med tidligere belastende livshendelser og psykiske problem. I avhandlingens seks delstudier har vi undersøkt noen aspekter ved fødselsangst og ønske om å bli forløst med keisersnitt, utfallet av den første fødselen til kvinner som har vært utsatt for voldtekt som voksen og seksuelle overgrep som barn, samt analysert ... -
Pulse oximetry in an adult population: Predictors of low oxygen saturation and associations with mortality; The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2015-03-19)Pulsoksymetri er en enkel undersøkelsesmetode for å beregne metningen av oksygen (O2) i arterielt blod (SpO2). Lave verdier kan være indikasjon på hjerte- og/eller lungesykdom. Ingen befolkningsundersøkelser har tidligere sett på oksygenmetning i en voksen befolkning. Avhandlingen er basert på de to befolkningsundersøkelsene, Tromsø 5 (2001/2002) og Tromsø 6 (2007/2008). I disse ble det gjort ...