<p>Tumours are highly complex tissues comprised of both malignant tumour cells and non-malignant healthy cells. Cells and tissues surrounding solid tumours make out the stroma, which provide physical support to the growing tumour structures, in addition to provide nutrients and facilitate waste removal. In the last four decades, it has become increasingly evident that stromal cells play important ...

Boares čállosat juoigama ja sámi kultuvrra birra govvidedje juoigama oassin buot eallima beliin sápmelaččas, leaš dál beaivválaš eallima doaimmain dahje vuoiŋŋalaš ja erenoamáš meanuin ja daguin. Juoigan govviduvvui dárbbašlažžan dearvvašvuhtii, čálgui ja lihkkui. Oanehaččat dadjon oažžot lohkat ahte luohti govviduvvui leame eallindárbun. Odne celket máŋga juoigi ahte luođis lea seamma mearkkašumi ...

Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ...

Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ...

Changed demographics and the prevalence of chronic, non-communicable, and infectious diseases create challenges in healthcare - lack of resources forces a transition from one-to-one to team-based approaches. Health professional education must prepare undergraduates for collaborative practice to ensure a collaborative-ready workforce that involves the patient as a partner. Interprofessional education ...

In this thesis, the possible benefits and challenges regarding taking part in a comprehensive individualized physiotherapy intervention, called I-CoreDIST and usual care physiotherapy following an acute stroke, along with patient perceptions of participation along the rehabilitation continuum are addressed. This is a mixed method study consisting of a randomised controlled trial (RCT) and an in-depth ...

<p><i>Why:</i> As low physical activity levels associate with ill health and mortality, continuous monitoring of physical activity levels is needed to inform policy. Identifying aetiology causes for the obesity epidemic is important to prevent population weight gain. However, there are still uncertainties on how physical activity and weight at population level associate over time, and how physical ...

<p><i>Klebsiella pneumoniae</i> is an opportunistic pathogen present in a wide range of environments. This species is often associated with antibiotic resistance and is a leading cause of health care associated infections but can also cause community acquired infections. Even though <i>K. pneumoniae</i> is extensively studied in clinical settings, less is known about its prevalence, antibiotic ...

In Scandinavian countries, resin-based composite materials have been used in restorative dentistry for over 30 years, replacing dental amalgams. Composite materials based on dimethacrylates provide better aesthetics and treatment options. However, according to in-vitro findings, dental composites can be affected by water, potentially reducing the longevity of dental restorations. The proper ...

Enterococci are gram-positive commensals in the human gut microbiota that may cause severe infections, especially in immunocompromised and hospitalised patients. Their ability to accumulate antimicrobial resistance and virulence genes has been vital in their evolution into leading pathogens. Vancomycin resistant enterococci (VRE) are among the most important resistant pathogens causing outbreaks ...