Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ...

Changed demographics and the prevalence of chronic, non-communicable, and infectious diseases create challenges in healthcare - lack of resources forces a transition from one-to-one to team-based approaches. Health professional education must prepare undergraduates for collaborative practice to ensure a collaborative-ready workforce that involves the patient as a partner. Interprofessional education ...

In this thesis, the possible benefits and challenges regarding taking part in a comprehensive individualized physiotherapy intervention, called I-CoreDIST and usual care physiotherapy following an acute stroke, along with patient perceptions of participation along the rehabilitation continuum are addressed. This is a mixed method study consisting of a randomised controlled trial (RCT) and an in-depth ...

<p><i>Why:</i> As low physical activity levels associate with ill health and mortality, continuous monitoring of physical activity levels is needed to inform policy. Identifying aetiology causes for the obesity epidemic is important to prevent population weight gain. However, there are still uncertainties on how physical activity and weight at population level associate over time, and how physical ...

<p><i>Klebsiella pneumoniae</i> is an opportunistic pathogen present in a wide range of environments. This species is often associated with antibiotic resistance and is a leading cause of health care associated infections but can also cause community acquired infections. Even though <i>K. pneumoniae</i> is extensively studied in clinical settings, less is known about its prevalence, antibiotic ...

In Scandinavian countries, resin-based composite materials have been used in restorative dentistry for over 30 years, replacing dental amalgams. Composite materials based on dimethacrylates provide better aesthetics and treatment options. However, according to in-vitro findings, dental composites can be affected by water, potentially reducing the longevity of dental restorations. The proper ...

Enterococci are gram-positive commensals in the human gut microbiota that may cause severe infections, especially in immunocompromised and hospitalised patients. Their ability to accumulate antimicrobial resistance and virulence genes has been vital in their evolution into leading pathogens. Vancomycin resistant enterococci (VRE) are among the most important resistant pathogens causing outbreaks ...

Oral squamous cell carcinomas (OSSCs) are aggressive tumors often associated with a low survival rate. The immune system influences the development of OSCCs, and the immune infiltrate surrounding the cancer cells is an indicator of the host’s anti-tumor response. The main aim of this thesis was to describe how the tumor microenvironment in OSCC is organized, and to determine whether different subsets ...

Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and multicausal disease. Obesity is a major and likely causal risk factor for VTE. However, to what extent obesity contributes to VTE risk in the general population and the mechanism of obesity-related VTE remain poorly understood. The overall aim of this thesis was (i) to ...

Perinatal periode er en krevende overgang i livet, som medfører økt risiko for psykiske helseutfordringer. Nedsatt psykisk helse hos foreldrene utgjør risiko for foreldre-barn relasjonen og for barnets utvikling. Gjennom samspillet med sine omsorgsgivere utvikler barnet emosjonsregulering og sosiale ferdigheter. Foreldre som blir fanget i repeterende negative tanker kan ha lite kapasitet til å plukke ...