Steroid receptor co-activator-3 (SRC-3) is a co-activator that plays important roles in normal physiology and different diseases including cancer. Its activity is regulated by phosphorylation. Serine 857 (S857) is the most frequently reported phosphorylation site of SRC-3. In this work, we examined several kinases that could phosphorylate SRC-3 at S857 and explored the functional outcome incurred ...

Helse- og sosialarbeidere, i private og offentlige arbeids- og velferdstjenester, har daglig kontakt med mennesker som har traumeerfaringer og sammensatte behov. Kommunikasjonen kan være følelsesmessig utfordrende og mange fagpersoner opplever dårlig tid, utrygghet og stress i arbeidet. Utrygghet og stress øker konfliktnivået og har en negativ effekt på fagpersoners velvære, holdninger til tjenestebrukere ...

The total prevalence of diabetes and vascular complications is increasing. Consequently, it is important to provide diabetes treatment according to the National clinical guideline for the management of diabetes and allocate individuals to the right level of health care in line with the National guideline for prioritization in specialist health care – Endocrinology and endocrine surgery. We used data ...

The physiological changes that occur during the pregnancy are known to affect women´s oral health. Pregnant women are more vulnerable to oral diseases when compared to non-pregnant. Better understanding of the relation between changing oral microbial milieu and risk of pregnancy complications and associated mechanisms could help to improve maternal and perinatal outcomes. Thus, we aimed to investigate ...

Interleukin-1β (IL-1β) is a pleiotropic inflammatory cytokine that exerts multiple roles in both physiological and pathological conditions. Enhanced IL-1β signaling drives hematopoietic stem cell (HSC) differentiation into the myeloid lineage and is actively involved in the development and progression of hematological malignancies, including deadly acute myeloid leukemia (AML). Inhibition of IL-1β ...

The overall aim of this thesis is to provide knowledge on potentially inappropriate medications (PIMs) in hospitalized older patients and to investigate how clinical pharmacist services in an interdisciplinary setting can contribute to medication optimization and improve patient outcomes. First, we used national health registers to investigate how admissions to Norwegian geriatric hospital wards ...

<p><i>Background:</i> Air embolism may complicate many medical procedures and cause vascular occlusion, organ infarctions, or death. In vitro, air triggers the alternative complement pathway and activates platelets. Previous studies of air emboli were conducted in serum, plasma, or heparin anticoagulated whole blood, with ambient air present in tubes, precluding detailed examination of thromboinflammation. ...

The overall aim of this thesis was to increase our knowledge related to the underlying mechanisms of diabetes-induced cardiomyopathy. The primary objective of the first two papers was to elucidate the role of the reactive oxygen species (ROS) producing enzyme, NADPH oxidase 2 (NOX2), in the development of cardiac dysfunction in obesity/diabetes. We also wanted to examine the potential link between ...

<p>The overall theme of this thesis is geographic and socioeconomic variation in the use of specialist health care services. Three different health care services were studied. Complete population data on individual level with high level of quality from nationwide registries (i.e., The Norwegian Patient Registry, The Cancer Registry of Norway and Statistics Norway) were used in the analysis. <p>The ...

Nanocarriers have brought several medical advances through better diagnostics and improved drug therapy. Yet, many promising preclinical findings were never translated into clinical success, consequently slowing drug development, and increasing its financial burden. By reliably predicting the nanoparticle fate at in vitro stages, the disappointment of suboptimal in vivo outcome could be avoided. To ...