Blar i forfatter Artikler, rapporter og annet (medisinsk biologi) "Østerud, Bjarne"

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    • Anti-β2-glycoprotein I autoantibodies influence thrombin generation parameters via various mechanisms 

      Szabó, Gábor; Debreceni, Ildikó Beke; Tarr, Tünde; Soltesz, P.; Østerud, Bjarne; Kappelmayer, János (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-06)
      Introduction<p> Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by recurrent thrombotic events, pregnancy loss and thrombocytopenia and the presence of antiphospholipid antibodies (APL). The exact pathomechanism of APS is still unknown, thus we investigated the effect of anti-β2-glycoprotein I (anti-β2GPI) on thrombin generation in different plasma samples.<p> <p>Methods ...

    • Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin 

      Kostovski, Emil; Dahm, Anders Erik A; Mowinckel, Marie-Christine; Stranda, Annicke; Skretting, Grethe; Østerud, Bjarne; Sandset, Per Morten; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-03)
      Study design: This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.<p> <p>Objectives: Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we ...

    • Detection of tissue factor in platelets: why is it so troublesome? 

      Østerud, Bjarne; Bouchard, Beth A (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-30)
      Tissue factor (TF) is the most important trigger for the extrinsic coagulation pathway. TF, earlier denoted as thromboplastin, has always been a mystery since its discovery due to its abundant presence in most human tissues but not blood. The latter has been extensively studied in a vast quest for possible sources of blood-borne TF yielding many conflicting findings and confusing conclusions regarding ...

    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...